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Pregled bibliografske jedinice broj: 121002

Kinetic Resolution of Diastereomeric Racemates of 7-Bromo-3-(1`-hydroxy-ethyl)-1-methyl-5-(2`-pyridyl)-2, 3-dihydro-1H-1, 4-benzodiazepin-2-one by Immobilized CAL-B


Majerić-Elenkov, Maja; Hameršak, Zdenko; Šunjić, Vitomir
Kinetic Resolution of Diastereomeric Racemates of 7-Bromo-3-(1`-hydroxy-ethyl)-1-methyl-5-(2`-pyridyl)-2, 3-dihydro-1H-1, 4-benzodiazepin-2-one by Immobilized CAL-B // Tetrahedron: asymmetry, 14 (2003), -; 2725-2730 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 121002 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Kinetic Resolution of Diastereomeric Racemates of 7-Bromo-3-(1`-hydroxy-ethyl)-1-methyl-5-(2`-pyridyl)-2, 3-dihydro-1H-1, 4-benzodiazepin-2-one by Immobilized CAL-B

Autori
Majerić-Elenkov, Maja ; Hameršak, Zdenko ; Šunjić, Vitomir

Izvornik
Tetrahedron: asymmetry (0957-4166) 14 (2003); 2725-2730

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Kinetic Resolution; Diastereomeric Racemates

Sažetak
Immobilized CAL-B catalyzed kinetic resolution of syn-7-bromo-3-(1`-hydroxy-ethyl)-1-methyl-5-(2`-pyridyl)-2, 3-dihydro-1H-1, 4-benzodiazepin-2-one syn-( )-2) and its anti-diastereomer ( )-3) are achieved with E-values over 200. Completely enantioselective acetylation of (1´R)-enantiomers in diastereomeric racemates with opposite configuration at the second stereogenic center C(3) occurs at substantially different rate (t1/2syn/t1/2anti ca 1/20). Conformational origins of enantioselection are discussed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
0098050

Ustanove:
Institut "Ruđer Bošković", Zagreb


Citiraj ovu publikaciju:

Majerić-Elenkov, Maja; Hameršak, Zdenko; Šunjić, Vitomir
Kinetic Resolution of Diastereomeric Racemates of 7-Bromo-3-(1`-hydroxy-ethyl)-1-methyl-5-(2`-pyridyl)-2, 3-dihydro-1H-1, 4-benzodiazepin-2-one by Immobilized CAL-B // Tetrahedron: asymmetry, 14 (2003), -; 2725-2730 (međunarodna recenzija, članak, znanstveni)
Majerić-Elenkov, M., Hameršak, Z. & Šunjić, V. (2003) Kinetic Resolution of Diastereomeric Racemates of 7-Bromo-3-(1`-hydroxy-ethyl)-1-methyl-5-(2`-pyridyl)-2, 3-dihydro-1H-1, 4-benzodiazepin-2-one by Immobilized CAL-B. Tetrahedron: asymmetry, 14 (-), 2725-2730.
@article{article, year = {2003}, pages = {2725-2730}, keywords = {Kinetic Resolution, Diastereomeric Racemates}, journal = {Tetrahedron: asymmetry}, volume = {14}, number = {-}, issn = {0957-4166}, title = {Kinetic Resolution of Diastereomeric Racemates of 7-Bromo-3-(1`-hydroxy-ethyl)-1-methyl-5-(2`-pyridyl)-2, 3-dihydro-1H-1, 4-benzodiazepin-2-one by Immobilized CAL-B}, keyword = {Kinetic Resolution, Diastereomeric Racemates} }
@article{article, year = {2003}, pages = {2725-2730}, keywords = {Kinetic Resolution, Diastereomeric Racemates}, journal = {Tetrahedron: asymmetry}, volume = {14}, number = {-}, issn = {0957-4166}, title = {Kinetic Resolution of Diastereomeric Racemates of 7-Bromo-3-(1`-hydroxy-ethyl)-1-methyl-5-(2`-pyridyl)-2, 3-dihydro-1H-1, 4-benzodiazepin-2-one by Immobilized CAL-B}, keyword = {Kinetic Resolution, Diastereomeric Racemates} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus





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