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Pregled bibliografske jedinice broj: 1209560

Human Adenovirus Type 26 Infection Mediated by αvβ3 Integrin Is Caveolin-1-Dependent


Nestić, Davor; Custers, Jerome; Švec, Danijel; Majhen, Dragomira
Human Adenovirus Type 26 Infection Mediated by αvβ3 Integrin Is Caveolin-1-Dependent // Microbiology Spectrum, 10 (2022), 4; e01097-22, 17 doi:10.1128/spectrum.01097-22 (međunarodna recenzija, članak, znanstveni)


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Naslov
Human Adenovirus Type 26 Infection Mediated by αvβ3 Integrin Is Caveolin-1-Dependent

Autori
Nestić, Davor ; Custers, Jerome ; Švec, Danijel ; Majhen, Dragomira

Izvornik
Microbiology Spectrum (2165-0497) 10 (2022), 4; E01097-22, 17

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
αvβ3 integrin ; human adenovirus type 26 infection ; adenovirus cell entry, caveolin-1, clathrin, dynamin-2, internalization, non-enveloped DNA virus ; vaccine vector ; virus endocytosis

Sažetak
Human adenovirus type 26 (HAdV26) has been recognized as a promising platform for vaccine vector development, and very recently vaccine against COVID-19 based on HAdV26 was authorized for emergency use. Nevertheless, basic biology of this virus, namely, pathway which HAdV26 uses to enter the cell, is still insufficiently known. We have shown here that HAdV26 infection of human epithelial cells expressing low amount of αvβ3 integrin involves clathrin and is caveolin-1- independent, while HAdV26 infection of cells with high amount of αvβ3 integrin does not involve clathrin but is caveolin-1-dependent. Thus, this study demonstrates that caveolin-1 is limiting factor in αvβ3 integrin-mediated HAdV26 infection. Regardless of αvβ3 integrin expression, HAdV26 infection involves dynamin-2. Our data provide for the first-time description of HAdV26 cell entry pathway, hence increase our knowledge of HAdV26 infection. Knowing that functionality of adenovirus vector is influenced by its cell entry pathway and intracellular trafficking, our results will contribute to better understanding of HAdV26 immunogenicity and antigen presentation when used as vaccine vector.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
HRZZ-IP-2019-04-6048 - Endocitoza adenovirusa i urođeni imunosni odgovor (AdenoIN) (Majhen, Dragomira, HRZZ - 2019-04) ( POIROT)
UIP-2014-09-3912 - Razumijevanje puta ulaska Adenovirusa tipa 26 u stanicu: način poboljšanja vektora za vakcinaciju (AdVEntPathVac) (Majhen, Dragomira, HRZZ - 2014-09) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Dragomira Majhen (autor)

Avatar Url Davor Nestić (autor)

Poveznice na cjeloviti tekst rada:

doi journals.asm.org doi.org

Citiraj ovu publikaciju:

Nestić, Davor; Custers, Jerome; Švec, Danijel; Majhen, Dragomira
Human Adenovirus Type 26 Infection Mediated by αvβ3 Integrin Is Caveolin-1-Dependent // Microbiology Spectrum, 10 (2022), 4; e01097-22, 17 doi:10.1128/spectrum.01097-22 (međunarodna recenzija, članak, znanstveni)
Nestić, D., Custers, J., Švec, D. & Majhen, D. (2022) Human Adenovirus Type 26 Infection Mediated by αvβ3 Integrin Is Caveolin-1-Dependent. Microbiology Spectrum, 10 (4), e01097-22, 17 doi:10.1128/spectrum.01097-22.
@article{article, author = {Nesti\'{c}, Davor and Custers, Jerome and \v{S}vec, Danijel and Majhen, Dragomira}, year = {2022}, pages = {17}, DOI = {10.1128/spectrum.01097-22}, chapter = {e01097-22}, keywords = {αvβ3 integrin, human adenovirus type 26 infection, adenovirus cell entry, caveolin-1, clathrin, dynamin-2, internalization, non-enveloped DNA virus, vaccine vector, virus endocytosis}, journal = {Microbiology Spectrum}, doi = {10.1128/spectrum.01097-22}, volume = {10}, number = {4}, issn = {2165-0497}, title = {Human Adenovirus Type 26 Infection Mediated by αvβ3 Integrin Is Caveolin-1-Dependent}, keyword = {αvβ3 integrin, human adenovirus type 26 infection, adenovirus cell entry, caveolin-1, clathrin, dynamin-2, internalization, non-enveloped DNA virus, vaccine vector, virus endocytosis}, chapternumber = {e01097-22} }
@article{article, author = {Nesti\'{c}, Davor and Custers, Jerome and \v{S}vec, Danijel and Majhen, Dragomira}, year = {2022}, pages = {17}, DOI = {10.1128/spectrum.01097-22}, chapter = {e01097-22}, keywords = {αvβ3 integrin, human adenovirus type 26 infection, adenovirus cell entry, caveolin-1, clathrin, dynamin-2, internalization, non-enveloped DNA virus, vaccine vector, virus endocytosis}, journal = {Microbiology Spectrum}, doi = {10.1128/spectrum.01097-22}, volume = {10}, number = {4}, issn = {2165-0497}, title = {Human Adenovirus Type 26 Infection Mediated by αvβ3 Integrin Is Caveolin-1-Dependent}, keyword = {αvβ3 integrin, human adenovirus type 26 infection, adenovirus cell entry, caveolin-1, clathrin, dynamin-2, internalization, non-enveloped DNA virus, vaccine vector, virus endocytosis}, chapternumber = {e01097-22} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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