engleski

Can extended hematological parameters of inflammation predict the severity and outcome of AECOPD?

Novel hematological parameters such as immature granulocytes (IG), activated neutrophils (NEUT-GI, NEUT-RI) and lymphocytes (RE-LYMP, AS-LYMP) are shown to be valuable for detecting and monitoring infections and inflammations. Our aim was to assess the connection between these parameters and the severity and outcome of COPD exacerbations (AECOPD). 90 patients with AECOPD who visited our pulmonary emergency room from May to August 2018 were included in this retrospective study. Patients’ sex, age, therapy, smoking status, laboratory findings, comorbidities, spirometry results, blood gas analysis, hospitalization or discharge from the ER, duration of hospitalization and survival were evaluated. Hematological parameters were determined by flow cytometry method on a SYSMEX XN-1000 hematological analyzer. Pearson’s correlation test, Chi square and t-test were used for data analysis. 52 patients were male (58%) and 38 female (42%). There were 57 active smokers (64%), 5 former smokers (5.5%) and 28 non- smokers (31%). All patients had comorbidities, mostly hypertension (75, 5%) and diabetes (20%). 19 were admitted to the hospital (21%), and 4 died (4.4%). Correlation between CRP and IG (r=0.363) and NEUT-GI (r=0.230) was low positive, and between CRP and AS-LYMP (r=-0.068), RE-LYMP (r=-0.039) and NEUT-RI (r=-0.251) was low negative. There was no significant difference in these parameters between patients who were discharged from the ER and those who were hospitalized, as well as between patients who died and those who survived. In conclusion, further research on a larger number of patients is required, given these parameters could be promising new biomarkers of inflammation.

COPD, hematological parameters

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