engleski

P077 Vaccination of patients with cystic fibrosis during the COVID-19 pandemic in Croatia

Objectives: Vaccination against COVID-19 is a major public health challenge in the general population. Patients with CF are considered highly vulnerable individuals due to their increased risk of developing severe forms of respiratory infections. In this study, we aimed to evaluate the prevalence of vaccination status against COVID-19 and influenza among patients with CF in a Croatian adult centre. Methods: A single-centre study was conducted at the Adult CF Centre that provides care to all adult CF patients in Croatia. It is based at the Clinic for Lung Diseases at the University Hospital Centre Zagreb. The outcomes of this study were prevalences of COVID-19 and influenza vaccination. Results: The total number of CF patients enrolled in the study was 41 (44% male, 56% female). Median age was 26 (18–37) years and median BMI was 20 (18–27) kg/m2 . Among the participants, 23 (55%) were vaccinated. Eight (20%) of them received ChAdOx1 (AstraZeneca) vaccine, 12 (29%) BNT162b2 (Pfizer) vaccine and 3 (7%) of them received mRNA-1273 (Moderna) vaccine. Only 12 (29%) patients had a booster dose. Seven (17%) patients had 3 doses of an mRNA vaccine and 5 (12%) of them were vaccinated with a combination of viral vector vaccine with a mRNA vaccine in third dose. In addition, among the participants, only 18 (44%) of them were vaccinated against influenza. Conclusion: The overall prevalence of COVID-19 and influenza vaccination among CF patients was lower than World Health Organization recommendation. A majority of the unvaccinated adult CF patients are from southern Croatia, which has the lowest vaccination status in Croatia. Unfavorable attitudes toward vaccination could be related to cultural, social and political influences. Therefore, it is imperative that pulmonology providers offer vaccinations to CF patients as well as direct vaccination guidance to help educate them about safety and efficacy of the vaccine, as regards COVID-19 and influenza.

cystic fibrosis ; COVID 19 ; vaccination

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