engleski

Učinak nedostatka proteina Tff3 na ekspresiju gena povezanih s neurodegeneracijom hipokampusa u mišjem modelu starenja

The increase in the incidence of neurodegenerative diseases is a reflection of complex cumulative processes during aging which involve the interactions of numerous organ systems. Decreased levels of Trefoil factor 3 (Tff3) protein in the cerebrospinal fluid of patients with Alzheimer’s disease indicate its possible role in neurodegenerative processes. Tff3 is involved in a variety of processes such as healing of mucosal surfaces in the gastrointestinal tract and apoptosis, migration, and angiogenesis, while its role in neural tissue is still unknown. In this paper, we hypothesized that Tff3 protein deficiency leads to a greater affinity of mice for the development of neurodegenerative processes, which we measured through the relative expression of the following genes:brain-derived neurotrophic factor (Bdnf), exchange protein directly activated by cAMP 2 (Epac2), epidermal growth factor receptor (Egfr), neurofilament light protein (Nfl) and L1 cell adhesion molecule (L1cam). Two - year - old mice of the Tff3 -/- C57Bl6/NCrl genotype and appropriate Wt controls were used in this study. Our results showed that Tff3 protein deficiency does not affect the expression of the observed genes involved in neurodegenerative processes.

Bdnf ; Egfr ; Epac2 ; hippocampus ; L1cam ; neurogenesis ; neuroplasticity ; Nfl

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