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Pregled bibliografske jedinice broj: 1207435

Genetic Landscape of the ACE2 Coronavirus Receptor


Yang, Zhijian; Macdonald-Dunlop, Erin; Chen, Jiantao; Zhai, Ranran; Li, Ting; Richmond, Anne; Klarić, Lucija; Pirastu, Nicola; Ning, Zheng; Zheng, Chenqing et al.
Genetic Landscape of the ACE2 Coronavirus Receptor // Circulation, 145 (2022), 18; 1398-1411 doi:10.1161/CIRCULATIONAHA.121.057888 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1207435 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genetic Landscape of the ACE2 Coronavirus Receptor

Autori
Yang, Zhijian ; Macdonald-Dunlop, Erin ; Chen, Jiantao ; Zhai, Ranran ; Li, Ting ; Richmond, Anne ; Klarić, Lucija ; Pirastu, Nicola ; Ning, Zheng ; Zheng, Chenqing ; Wang, Yipeng ; Huang, Tingting ; He, Yazhou ; Guo, Huiming ; Ying, Kejun ; Gustafsson, Stefan ; Prins, Bram ; Ramisch, Anna ; Dermitzakis, Emmanouil T. ; Png, Grace ; Eriksson, Niclas ; Haessler, Jeffrey ; Hu, Xiaowei ; Zanetti, Daniela ; Boutin, Thibaud ; Hwang, Shih- Jen ; Wheeler, Eleanor ; Pietzner, Maik ; Raffield, Laura M. ; Kalnapenkis, Anette ; Peters, James E. ; Viñuela, Ana ; Gilly, Arthur ; Elmståhl, Sölve ; Dedoussis, George ; Petrie, John R. ; Polašek, Ozren ; Folkersen, Lasse ; Chen, Yan ; Yao, Chen ; Võsa, Urmo ; Pairo-Castineira, Erola ; Clohisey, Sara ; Bretherick, Andrew D. ; Rawlik, Konrad ; Esko, Tõnu ; Enroth, Stefan ; Johansson, Åsa ; Gyllensten, Ulf ; Langenberg, Claudia ; Levy, Daniel ; Hayward, Caroline ; Assimes, Themistocles L. ; Kooperberg, Charles ; Manichaikul, Ani W. ; Siegbahn, Agneta ; Wallentin, Lars ; Lind, Lars ; Zeggini, Eleftheria ; Schwenk, Jochen M. ; Butterworth, Adam S. ; Michaëlsson, Karl ; Pawitan, Yudi ; Joshi, Peter K. ; Baillie, J. Kenneth ; Mälarstig, Anders ; Reiner, Alexander P. ; Wilson, James F. ; Shen, Xia ; GenOMICC Consortium† ; IMI-DIRECT Consortium†

Izvornik
Circulation (0009-7322) 145 (2022), 18; 1398-1411

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
COVID ; genetic ; analysis

Sažetak
Background: SARS-CoV-2, the causal agent of COVID- 19, enters human cells using the ACE2 (angiotensin-converting enzyme 2) protein as a receptor. ACE2 is thus key to the infection and treatment of the coronavirus. ACE2 is highly expressed in the heart and respiratory and gastrointestinal tracts, playing important regulatory roles in the cardiovascular and other biological systems. However, the genetic basis of the ACE2 protein levels is not well understood. Methods: We have conducted the largest genome-wide association meta-analysis of plasma ACE2 levels in >28 000 individuals of the SCALLOP Consortium (Systematic and Combined Analysis of Olink Proteins). We summarize the cross-sectional epidemiological correlates of circulating ACE2. Using the summary statistics-based high-definition likelihood method, we estimate relevant genetic correlations with cardiometabolic phenotypes, COVID-19, and other human complex traits and diseases. We perform causal inference of soluble ACE2 on vascular disease outcomes and COVID-19 severity using mendelian randomization. We also perform in silico functional analysis by integrating with other types of omics data. Results: We identified 10 loci, including 8 novel, capturing 30% of the heritability of the protein. We detected that plasma ACE2 was genetically correlated with vascular diseases, severe COVID- 19, and a wide range of human complex diseases and medications. An X-chromosome cis-protein quantitative trait loci-based mendelian randomization analysis suggested a causal effect of elevated ACE2 levels on COVID-19 severity (odds ratio, 1.63 [95% CI, 1.10-2.42] ; P=0.01), hospitalization (odds ratio, 1.52 [95% CI, 1.05- 2.21] ; P=0.03), and infection (odds ratio, 1.60 [95% CI, 1.08-2.37] ; P=0.02). Tissue- and cell type-specific transcriptomic and epigenomic analysis revealed that the ACE2 regulatory variants were enriched for DNA methylation sites in blood immune cells. Conclusions: Human plasma ACE2 shares a genetic basis with cardiovascular disease, COVID-19, and other related diseases. The genetic architecture of the ACE2 protein is mapped, providing a useful resource for further biological and clinical studies on this coronavirus receptor.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Split,
Visoko učilište Algebra, Zagreb

Profili:

Avatar Url Ozren Polašek (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Yang, Zhijian; Macdonald-Dunlop, Erin; Chen, Jiantao; Zhai, Ranran; Li, Ting; Richmond, Anne; Klarić, Lucija; Pirastu, Nicola; Ning, Zheng; Zheng, Chenqing et al.
Genetic Landscape of the ACE2 Coronavirus Receptor // Circulation, 145 (2022), 18; 1398-1411 doi:10.1161/CIRCULATIONAHA.121.057888 (međunarodna recenzija, članak, znanstveni)
Yang, Z., Macdonald-Dunlop, E., Chen, J., Zhai, R., Li, T., Richmond, A., Klarić, L., Pirastu, N., Ning, Z. & Zheng, C. (2022) Genetic Landscape of the ACE2 Coronavirus Receptor. Circulation, 145 (18), 1398-1411 doi:10.1161/CIRCULATIONAHA.121.057888.
@article{article, author = {Yang, Zhijian and Macdonald-Dunlop, Erin and Chen, Jiantao and Zhai, Ranran and Li, Ting and Richmond, Anne and Klari\'{c}, Lucija and Pirastu, Nicola and Ning, Zheng and Zheng, Chenqing and Wang, Yipeng and Huang, Tingting and He, Yazhou and Guo, Huiming and Ying, Kejun and Gustafsson, Stefan and Prins, Bram and Ramisch, Anna and Dermitzakis, Emmanouil T. and Png, Grace and Eriksson, Niclas and Haessler, Jeffrey and Hu, Xiaowei and Zanetti, Daniela and Boutin, Thibaud and Hwang, Shih- Jen and Wheeler, Eleanor and Pietzner, Maik and Raffield, Laura M. and Kalnapenkis, Anette and Peters, James E. and Vi\~{n}uela, Ana and Gilly, Arthur and Elmst\aahl, S\"{o}lve and Dedoussis, George and Petrie, John R. and Pola\v{s}ek, Ozren and Folkersen, Lasse and Chen, Yan and Yao, Chen and V\~{o}sa, Urmo and Pairo-Castineira, Erola and Clohisey, Sara and Bretherick, Andrew D. and Rawlik, Konrad and Esko, T\~{o}nu and Enroth, Stefan and Johansson, \AAsa and Gyllensten, Ulf and Langenberg, Claudia and Levy, Daniel and Hayward, Caroline and Assimes, Themistocles L. and Kooperberg, Charles and Manichaikul, Ani W. and Siegbahn, Agneta and Wallentin, Lars and Lind, Lars and Zeggini, Eleftheria and Schwenk, Jochen M. and Butterworth, Adam S. and Micha\"{e}lsson, Karl and Pawitan, Yudi and Joshi, Peter K. and Baillie, J. Kenneth and M\"{a}larstig, Anders and Reiner, Alexander P. and Wilson, James F. and Shen, Xia}, year = {2022}, pages = {1398-1411}, DOI = {10.1161/CIRCULATIONAHA.121.057888}, keywords = {COVID, genetic, analysis}, journal = {Circulation}, doi = {10.1161/CIRCULATIONAHA.121.057888}, volume = {145}, number = {18}, issn = {0009-7322}, title = {Genetic Landscape of the ACE2 Coronavirus Receptor}, keyword = {COVID, genetic, analysis} }
@article{article, author = {Yang, Zhijian and Macdonald-Dunlop, Erin and Chen, Jiantao and Zhai, Ranran and Li, Ting and Richmond, Anne and Klari\'{c}, Lucija and Pirastu, Nicola and Ning, Zheng and Zheng, Chenqing and Wang, Yipeng and Huang, Tingting and He, Yazhou and Guo, Huiming and Ying, Kejun and Gustafsson, Stefan and Prins, Bram and Ramisch, Anna and Dermitzakis, Emmanouil T. and Png, Grace and Eriksson, Niclas and Haessler, Jeffrey and Hu, Xiaowei and Zanetti, Daniela and Boutin, Thibaud and Hwang, Shih- Jen and Wheeler, Eleanor and Pietzner, Maik and Raffield, Laura M. and Kalnapenkis, Anette and Peters, James E. and Vi\~{n}uela, Ana and Gilly, Arthur and Elmst\aahl, S\"{o}lve and Dedoussis, George and Petrie, John R. and Pola\v{s}ek, Ozren and Folkersen, Lasse and Chen, Yan and Yao, Chen and V\~{o}sa, Urmo and Pairo-Castineira, Erola and Clohisey, Sara and Bretherick, Andrew D. and Rawlik, Konrad and Esko, T\~{o}nu and Enroth, Stefan and Johansson, \AAsa and Gyllensten, Ulf and Langenberg, Claudia and Levy, Daniel and Hayward, Caroline and Assimes, Themistocles L. and Kooperberg, Charles and Manichaikul, Ani W. and Siegbahn, Agneta and Wallentin, Lars and Lind, Lars and Zeggini, Eleftheria and Schwenk, Jochen M. and Butterworth, Adam S. and Micha\"{e}lsson, Karl and Pawitan, Yudi and Joshi, Peter K. and Baillie, J. Kenneth and M\"{a}larstig, Anders and Reiner, Alexander P. and Wilson, James F. and Shen, Xia}, year = {2022}, pages = {1398-1411}, DOI = {10.1161/CIRCULATIONAHA.121.057888}, keywords = {COVID, genetic, analysis}, journal = {Circulation}, doi = {10.1161/CIRCULATIONAHA.121.057888}, volume = {145}, number = {18}, issn = {0009-7322}, title = {Genetic Landscape of the ACE2 Coronavirus Receptor}, keyword = {COVID, genetic, analysis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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