engleski

Spectrum of radiological imaging findings of immune-checkpoint blockade for lung cancer at University hospital centre Osijek

Cancer immunotherapy based on immune-checkpoint blockade has resulted in yet another paradigm shift in advanced cancer treatment.ICIs block tumor-induced immune inhibitionand thereby activate cellular immune response against tumors. Programmed death-1 (PD-1) and programmed death- ligand 1 (PD-L1) inhibitors are two major groups of agents used in the treatment of advanced NSCLC. Prior to ICIs introduction, the mainstay of treatment for patients with advanced NSCLC who had no targetable mutations was cytotoxic chemotherapy, but without meaningful improvement in outcomes.

hyperprogression ; NSCLC ; PD-L1 pseudoprogression

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