Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1206114

Downregulation of NLRP3, CASP1 and IL1B expression in COPD patients after lung transplantation


Markelić , Ivona; Rumora, Lada; Hlapčić, Iva; Džubur, Feđa; Popović Grle, Sanja; Samaržija, Miroslav; Vukić Dugac; Andrea
Downregulation of NLRP3, CASP1 and IL1B expression in COPD patients after lung transplantation // European Respiratory Society (ERS) International Congress 2022
Barcelona, Španjolska, 2022. str. x-x (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1206114 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Downregulation of NLRP3, CASP1 and IL1B expression in COPD patients after lung transplantation

Autori
Markelić , Ivona ; Rumora, Lada ; Hlapčić, Iva ; Džubur, Feđa ; Popović Grle, Sanja ; Samaržija, Miroslav ; Vukić Dugac ; Andrea

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
European Respiratory Society (ERS) International Congress 2022

Mjesto i datum
Barcelona, Španjolska, 04–06.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Chronic obstructive pulmonary disease ; Lung transplantation ; NLRP3 ; CASP1 ; IL1B

Sažetak
Introduction: Emerging evidence suggests that the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome plays an important role in the pathogenesis of COPD. Moreover, it may be involved in ongoing chronic inflammation that is present in patients with end-stage COPD who are candidates for lung transplantation (LT). Aims and objectives: The aim of this study was to determine the gene expression of NLRP3, caspase-1 (CASP1) and interleukin-1β (IL1B) in 5 patients with COPD before LT and 1 year after LT. Methods: Gene expression was examined by qPCR in the peripheral blood samples using the commercial TaqMan gene expression assays (Applied Biosystems, Foster City, CA, USA). The calculation of the relative mRNA expression was performed by the 2−∆∆Ct method. Spirometry parameters were determined before and after LT while symptoms burden, history of exacerbations and health status were assessed by mMRC, CAT and SGRQ-C scores. Results were statistically significant if P 0.05. Results: Gene expressions of NLRP3, CASP1 and IL1B were significantly downregulated in patients one year after LT (P = 0.009, P = 0.014, P = 0.005, respectively). On the other hand, spirometry values were significantly increased at 1-year post-transplantation period with FEV1 (L) increasing from 0.59 to 3.22 (P = 0.001) and FVC (L) from 1.81 to 3.57 (P = 0.010). In addition, significant improvements in mMRC, CAT and SGRQ-C scores were observed after LT (P = 0.041, P = 0.035 and P = 0.015, respectively). Conclusions: NLRP3, CASP1 and IL1B expression were decreased in lung transplant recipients with COPD one year after LT, suggesting a significant involvement of NLRP3 inflammasome in severe COPD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
IP-2014-09-1247 - Uloga stresnog proteina Hsp70 u imunosno-upalnom odgovoru kod kronične opstrukcijske plućne bolesti (Hsp70COPD) (HRZZ - 2014-09) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinika za plućne bolesti "Jordanovac"


Citiraj ovu publikaciju:

Markelić , Ivona; Rumora, Lada; Hlapčić, Iva; Džubur, Feđa; Popović Grle, Sanja; Samaržija, Miroslav; Vukić Dugac; Andrea
Downregulation of NLRP3, CASP1 and IL1B expression in COPD patients after lung transplantation // European Respiratory Society (ERS) International Congress 2022
Barcelona, Španjolska, 2022. str. x-x (poster, međunarodna recenzija, sažetak, znanstveni)
Markelić , I., Rumora, L., Hlapčić, I., Džubur, F., Popović Grle, S., Samaržija, M., Vukić Dugac & Andrea (2022) Downregulation of NLRP3, CASP1 and IL1B expression in COPD patients after lung transplantation. U: European Respiratory Society (ERS) International Congress 2022.
@article{article, author = {Markeli\'{c}, Ivona and Rumora, Lada and Hlap\v{c}i\'{c}, Iva and D\v{z}ubur, Fe\dja and Popovi\'{c} Grle, Sanja and Samar\v{z}ija, Miroslav}, year = {2022}, pages = {x-x}, keywords = {Chronic obstructive pulmonary disease, Lung transplantation, NLRP3, CASP1, IL1B}, title = {Downregulation of NLRP3, CASP1 and IL1B expression in COPD patients after lung transplantation}, keyword = {Chronic obstructive pulmonary disease, Lung transplantation, NLRP3, CASP1, IL1B}, publisherplace = {Barcelona, \v{S}panjolska} }
@article{article, author = {Markeli\'{c}, Ivona and Rumora, Lada and Hlap\v{c}i\'{c}, Iva and D\v{z}ubur, Fe\dja and Popovi\'{c} Grle, Sanja and Samar\v{z}ija, Miroslav}, year = {2022}, pages = {x-x}, keywords = {Chronic obstructive pulmonary disease, Lung transplantation, NLRP3, CASP1, IL1B}, title = {Downregulation of NLRP3, CASP1 and IL1B expression in COPD patients after lung transplantation}, keyword = {Chronic obstructive pulmonary disease, Lung transplantation, NLRP3, CASP1, IL1B}, publisherplace = {Barcelona, \v{S}panjolska} }




Contrast
Increase Font
Decrease Font
Dyslexic Font