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Pregled bibliografske jedinice broj: 1206111

Activation of NLRP3 inflammasome in stable chronic obstructive pulmonary disease


Markelić, Ivona; Hlapčić, Iva; Ceri, Andrea; Radic Antolic, Margareta; Samaržija, Miroslav; Popović-Grle, Sanja; Vukić Dugac, Andrea; Rumora, Lada
Activation of NLRP3 inflammasome in stable chronic obstructive pulmonary disease // Scientific reports, 12 (2022), 7544, 8 doi:10.1038/s41598-022-11164-1 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1206111 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Activation of NLRP3 inflammasome in stable chronic obstructive pulmonary disease

Autori
Markelić, Ivona ; Hlapčić, Iva ; Ceri, Andrea ; Radic Antolic, Margareta ; Samaržija, Miroslav ; Popović-Grle, Sanja ; Vukić Dugac, Andrea ; Rumora, Lada

Izvornik
Scientific reports (2045-2322) 12 (2022); 7544, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Chronic obstructive pulmonary disease ; Interleukin-1beta ; NLRP3 inflammasome ; Gene expression

Sažetak
Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation plays an important role in chronic obstructive pulmonary disease (COPD) pathogenesis and might be involved in ongoing chronic inflammation. This study aimed to determine interleukin-1beta (IL-1β) plasma concentration as well as IL1B, NLRP3 and caspase-1 (CASP1) gene expression in the Croatian COPD patients. 109 patients with stable COPD and age- and sex-matched 95 controls were included in the study. Plasma IL-1β concentration was measured by Luminex technology, and gene expression analysis was performed using TaqMan assays. It was shown that COPD patients had increased concentration of IL-1β and enhanced gene expression of IL1B, NLRP3 and CASP1 compared to controls. There was no difference in IL-1β or IL1B, NLRP3 and CASP1 in patients with COPD regarding airflow obstruction severity and smoking history. Finally, the diagnostic potential of the determined parameters was evaluated, and it was found that IL-1β correctly classified 89% of cases in the combination with common inflammatory biomarkers, white blood cell count and fibrinogen, showing a potential in COPD prediction. In conclusion, up-regulation of IL1B, NLRP3, CASP1 and increased IL-1β concentration suggest the activation of NLRP3 inflammasome in the systemic compartment of patients with stable COPD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
IP-2014-09-1247 - Uloga stresnog proteina Hsp70 u imunosno-upalnom odgovoru kod kronične opstrukcijske plućne bolesti (Hsp70COPD) (HRZZ - 2014-09) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinika za plućne bolesti "Jordanovac",
Klinički bolnički centar Zagreb

Poveznice na cjeloviti tekst rada:

doi doi.org

Citiraj ovu publikaciju:

Markelić, Ivona; Hlapčić, Iva; Ceri, Andrea; Radic Antolic, Margareta; Samaržija, Miroslav; Popović-Grle, Sanja; Vukić Dugac, Andrea; Rumora, Lada
Activation of NLRP3 inflammasome in stable chronic obstructive pulmonary disease // Scientific reports, 12 (2022), 7544, 8 doi:10.1038/s41598-022-11164-1 (međunarodna recenzija, članak, znanstveni)
Markelić, I., Hlapčić, I., Ceri, A., Radic Antolic, M., Samaržija, M., Popović-Grle, S., Vukić Dugac, A. & Rumora, L. (2022) Activation of NLRP3 inflammasome in stable chronic obstructive pulmonary disease. Scientific reports, 12, 7544, 8 doi:10.1038/s41598-022-11164-1.
@article{article, author = {Markeli\'{c}, Ivona and Hlap\v{c}i\'{c}, Iva and Ceri, Andrea and Radic Antolic, Margareta and Samar\v{z}ija, Miroslav and Popovi\'{c}-Grle, Sanja and Vuki\'{c} Dugac, Andrea and Rumora, Lada}, year = {2022}, pages = {8}, DOI = {10.1038/s41598-022-11164-1}, chapter = {7544}, keywords = {Chronic obstructive pulmonary disease, Interleukin-1beta, NLRP3 inflammasome, Gene expression}, journal = {Scientific reports}, doi = {10.1038/s41598-022-11164-1}, volume = {12}, issn = {2045-2322}, title = {Activation of NLRP3 inflammasome in stable chronic obstructive pulmonary disease}, keyword = {Chronic obstructive pulmonary disease, Interleukin-1beta, NLRP3 inflammasome, Gene expression}, chapternumber = {7544} }
@article{article, author = {Markeli\'{c}, Ivona and Hlap\v{c}i\'{c}, Iva and Ceri, Andrea and Radic Antolic, Margareta and Samar\v{z}ija, Miroslav and Popovi\'{c}-Grle, Sanja and Vuki\'{c} Dugac, Andrea and Rumora, Lada}, year = {2022}, pages = {8}, DOI = {10.1038/s41598-022-11164-1}, chapter = {7544}, keywords = {Chronic obstructive pulmonary disease, Interleukin-1beta, NLRP3 inflammasome, Gene expression}, journal = {Scientific reports}, doi = {10.1038/s41598-022-11164-1}, volume = {12}, issn = {2045-2322}, title = {Activation of NLRP3 inflammasome in stable chronic obstructive pulmonary disease}, keyword = {Chronic obstructive pulmonary disease, Interleukin-1beta, NLRP3 inflammasome, Gene expression}, chapternumber = {7544} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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