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Pregled bibliografske jedinice broj: 1206068

Extra Virgin Olive Oil Secoiridoids Modulate the Metabolic Activity of Dacarbazine Pre-Treated and Treatment-Naive Melanoma Cells


Kugić, Azra; Dabelić, Sanja; Jakobušić Brala, Cvijeta; Dabelić, Nina; Barbarić, Monika
Extra Virgin Olive Oil Secoiridoids Modulate the Metabolic Activity of Dacarbazine Pre-Treated and Treatment-Naive Melanoma Cells // Molecules, 27 (2022), 10; 3310, 19 doi:10.3390/molecules27103310 (međunarodna recenzija, članak, znanstveni)


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Naslov
Extra Virgin Olive Oil Secoiridoids Modulate the Metabolic Activity of Dacarbazine Pre-Treated and Treatment-Naive Melanoma Cells

Autori
Kugić, Azra ; Dabelić, Sanja ; Jakobušić Brala, Cvijeta ; Dabelić, Nina ; Barbarić, Monika

Izvornik
Molecules (1420-3049) 27 (2022), 10; 3310, 19

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
melanoma cells ; olive oil ; secoiridoids ; oleocanthal ; oleacein ; dacarbazine ; 1HNMR ; HPLC-DAD

Sažetak
Nowadays, many individuals, whether healthy or diagnosed with disease, tend to expose themselves to various easily accessible natural products in hopes of benefiting their health and well-being. Mediterranean populations have traditionally used olive oil not only in nutrition but also in cosmetics, including skincare. In this study, the phenolic profile—composed of twelve compounds altogether, including the secoiridoids oleocanthal (OCAL) and oleacein (OCEIN)—of extra virgin olive oil (EVOO) from autochthonous cultivars from Croatia was determined using 1H qNMR spectroscopy and HPLC-DAD analysis, and its biological activity was investigated in melanoma cell lines. The EVOO with the highest OCEIN content had the strongest anti-cancer activity in A375 melanoma cells and the least toxic effect on the non- cancerous keratocyte cell line (HaCaT). On the other hand, pure OCAL was shown to be more effective and safer than pure OCEIN. Post-treatment with any of the EVOO phenolic extracts (EVOO-PEs) enhanced the anti-cancer effect of the anti-cancerous drug dacarbazine (DTIC) applied in pre-treatment, while they did not compromise the viability of non-cancerous cells. The metastatic melanoma A375M cell line was almost unresponsive to the EVOO-PEs themselves, as well as to pure OCEIN and OCAL. Our results demonstrate that olive oils and/or their compounds may have a potentially beneficial effect on melanoma treatment. However, their usage can be detrimental or futile, especially in healthy cells, due to inadequately applied concentrations/combinations or the presence of resistant cells.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekti:
EK-EFRR-KK.01.1.1.02.0021 - Jačanje znanstveno-istraživačkih i inovacijskih kapaciteta Farmaceutsko-biokemijskog fakulteta Sveučilišta u Zagrebu (FarmInova) (Lovrić, Jasmina, EK - Ulaganje u organizacijsku reformu i infrastrukturu u sektoru istraživanja, razvoja i inovacija) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
KBC "Sestre Milosrdnice"

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.mdpi.com

Citiraj ovu publikaciju:

Kugić, Azra; Dabelić, Sanja; Jakobušić Brala, Cvijeta; Dabelić, Nina; Barbarić, Monika
Extra Virgin Olive Oil Secoiridoids Modulate the Metabolic Activity of Dacarbazine Pre-Treated and Treatment-Naive Melanoma Cells // Molecules, 27 (2022), 10; 3310, 19 doi:10.3390/molecules27103310 (međunarodna recenzija, članak, znanstveni)
Kugić, A., Dabelić, S., Jakobušić Brala, C., Dabelić, N. & Barbarić, M. (2022) Extra Virgin Olive Oil Secoiridoids Modulate the Metabolic Activity of Dacarbazine Pre-Treated and Treatment-Naive Melanoma Cells. Molecules, 27 (10), 3310, 19 doi:10.3390/molecules27103310.
@article{article, author = {Kugi\'{c}, Azra and Dabeli\'{c}, Sanja and Jakobu\v{s}i\'{c} Brala, Cvijeta and Dabeli\'{c}, Nina and Barbari\'{c}, Monika}, year = {2022}, pages = {19}, DOI = {10.3390/molecules27103310}, chapter = {3310}, keywords = {melanoma cells, olive oil, secoiridoids, oleocanthal, oleacein, dacarbazine, 1HNMR, HPLC-DAD}, journal = {Molecules}, doi = {10.3390/molecules27103310}, volume = {27}, number = {10}, issn = {1420-3049}, title = {Extra Virgin Olive Oil Secoiridoids Modulate the Metabolic Activity of Dacarbazine Pre-Treated and Treatment-Naive Melanoma Cells}, keyword = {melanoma cells, olive oil, secoiridoids, oleocanthal, oleacein, dacarbazine, 1HNMR, HPLC-DAD}, chapternumber = {3310} }
@article{article, author = {Kugi\'{c}, Azra and Dabeli\'{c}, Sanja and Jakobu\v{s}i\'{c} Brala, Cvijeta and Dabeli\'{c}, Nina and Barbari\'{c}, Monika}, year = {2022}, pages = {19}, DOI = {10.3390/molecules27103310}, chapter = {3310}, keywords = {melanoma cells, olive oil, secoiridoids, oleocanthal, oleacein, dacarbazine, 1HNMR, HPLC-DAD}, journal = {Molecules}, doi = {10.3390/molecules27103310}, volume = {27}, number = {10}, issn = {1420-3049}, title = {Extra Virgin Olive Oil Secoiridoids Modulate the Metabolic Activity of Dacarbazine Pre-Treated and Treatment-Naive Melanoma Cells}, keyword = {melanoma cells, olive oil, secoiridoids, oleocanthal, oleacein, dacarbazine, 1HNMR, HPLC-DAD}, chapternumber = {3310} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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