Microwave assisted synthesis of biologically active 3-hydroxypyridin-4-ones (CROSBI ID 720661)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Car, Željka ; Petrović Peroković, Vesna
engleski
Microwave assisted synthesis of biologically active 3-hydroxypyridin-4-ones
3-Hydroxypyridin-4-ones (3, 4-HPs) have emerged as important substructures found in many natural and synthetic biologically active materials.1They are investigated as potential antibacterial, antidiabetic, antineurodegenerative and anticancer agents, as well as potential chelators in metal overload conditions.1Our recent investigations of this class of compounds have been focused on their in vitro antiproliferative and antiadhesive activity.2 Although versatile in their biological activities their synthesis remains a challenge. They can be prepared by either the direct or Harris method from maltol or the corresponding aniline derivative with or without the acidic catalyst.2The direct approach consists of heating the reactants in an autoclave for at least 48 h. The second, Harris method, includes the additional steps. We have investigated their microwave assisted synthesis and found it to be an effective and not so time-consuming alternative method for their preparation.
3-Hydroxypyridin-4-ones ; Biological activity ; Microwave assisted synthesis
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Podaci o prilogu
161-161.
2022.
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objavljeno
Podaci o matičnoj publikaciji
Glasnik hemičara i tehnologa Bosne i Hercegovine = Bulletin of the Chemists and Technologists of Bosnia and Herzegovina
Korać, Fehim
Sarajevo: Society of Chemists and Technologists of Canton Sarajevo
0367-4444
2232-7266
Podaci o skupu
4th International Congress of Chemists and Chemical Engineers of Bosnia and Herzegovina (ICCCEB&H 2022)
poster
30.06.2022-02.07.2022
Sarajevo, Bosna i Hercegovina