Synthesis of new heterocyclic resveratrol analogues in milli- and microreactors: intensification of the Wittig reaction (CROSBI ID 311903)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Mlakić, Milena ; Rajič, Lucija ; Ljubić Anabela ; Vušak Vitomir ; Zelić, Bruno ; Gojun, Martin ; Odak, Ilijana ; Čule, Ivona ; Šagud, Ivana ; Šalić, Anita ; Škorić, Irena
engleski
Synthesis of new heterocyclic resveratrol analogues in milli- and microreactors: intensification of the Wittig reaction
Resveratrol is a natural bioactive non- flavonoid polyphenol that protects from cardiovascular disease, neurodegenerative diseases and various cancers. Unfortunately, the amounts of resveratrol in plants are low and therefore, chemical synthesis is still the main way to obtain this valuable structure. In this work, Wittig reaction was chosen as the synthetic route for the study on technology influence in batch vs micro- or milliflow reactors during the production of new resveratrol-like compounds. A series of reactions was carried out by batch synthesis, and intensified in a milli- and a microreactor, changing the reaction conditions to increase the efficiency and productivity of the process. Results were compared based on conversion, yield, productivity and trans/cis ratio. Similar yields and conversions were obtained in all reaction systems, but in much shorter time in the milli- and microscale compared to the batch reactor. On the other hand, higher productivities were obtained in the millireactor and microreactor, making them better systems for the proposed reactions of new heterocyclic resveratrol analogues synthesis.
continuous flow ; resveratrol analogues ; milli- and microreactor ; process intensification
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Podaci o izdanju
12 (4)
2022.
429-440
objavljeno
2062-249X
2060-5587
10.1007/s41981-022-00239-9
Povezanost rada
Farmacija, Kemija, Kemijsko inženjerstvo