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Pregled bibliografske jedinice broj: 1204463

Key Factors for Thymic Function and Development


Shichkin, Valentin P.; Antica, Mariastefania
Key Factors for Thymic Function and Development // Frontiers in Immunology, 13 (2022), 926516, 18 doi:10.3389/fimmu.2022.926516 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
Key Factors for Thymic Function and Development

Autori
Shichkin, Valentin P. ; Antica, Mariastefania

Izvornik
Frontiers in Immunology (1664-3224) 13 (2022); 926516, 18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
thymus ; thymic epithelial cells (TEC) ; thymic microenvironment, thymus regeneration, T cells ; intrathymic regulators ; thymic stem cells

Sažetak
The thymus is the organ responsible for T cell development and the formation of the adaptive immunity function. Its multicellular environment consists mainly of the different stromal cells and maturing T lymphocytes. Thymus-specific progenitors of epithelial, mesenchymal, and lymphoid cells with stem cell properties represent only minor populations. The thymic stromal structure predominantly determines the function of the thymus. The stromal components, mostly epithelial and mesenchymal cells, form this specialized area. They support the consistent developmental program of functionally distinct conventional T cell subpopulations. These include the MHC restricted single positive CD4+ CD8- and CD4- CD8+ cells, regulatory T lymphocytes (Foxp3+), innate natural killer T cells (iNKT), and γδT cells. Several physiological causes comprising stress and aging and medical treatments such as thymectomy and chemo/radiotherapy can harm the thymus function. The present review summarizes our knowledge of the development and function of the thymus with a focus on thymic epithelial cells as well as other stromal components and the signaling and transcriptional pathways underlying the thymic cell interaction. These critical thymus components are significant for T cell differentiation and restoring the thymic function after damage to reach the therapeutic benefits.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2020-02-2431 - Obnova timusa za preciznu medicinu u liječenju tumora i leukemija (THYMINNOVA) (Antica, Mariastefania, HRZZ - 2020-02) ( POIROT)
EK-EFRR-KK.01.1.1.01.0008 - Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu – istraživanja novih platormi i potencijala (CERRM) (Volarević, Siniša; Vukičević, Slobodan; Ježek, Davor, EK - KK.01.1.1.01) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Mariastefania Antica (autor)

Poveznice na cjeloviti tekst rada:

doi www.frontiersin.org

Citiraj ovu publikaciju:

Shichkin, Valentin P.; Antica, Mariastefania
Key Factors for Thymic Function and Development // Frontiers in Immunology, 13 (2022), 926516, 18 doi:10.3389/fimmu.2022.926516 (međunarodna recenzija, pregledni rad, znanstveni)
Shichkin, V. & Antica, M. (2022) Key Factors for Thymic Function and Development. Frontiers in Immunology, 13, 926516, 18 doi:10.3389/fimmu.2022.926516.
@article{article, author = {Shichkin, Valentin P. and Antica, Mariastefania}, year = {2022}, pages = {18}, DOI = {10.3389/fimmu.2022.926516}, chapter = {926516}, keywords = {thymus, thymic epithelial cells (TEC), thymic microenvironment, thymus regeneration, T cells, intrathymic regulators, thymic stem cells}, journal = {Frontiers in Immunology}, doi = {10.3389/fimmu.2022.926516}, volume = {13}, issn = {1664-3224}, title = {Key Factors for Thymic Function and Development}, keyword = {thymus, thymic epithelial cells (TEC), thymic microenvironment, thymus regeneration, T cells, intrathymic regulators, thymic stem cells}, chapternumber = {926516} }
@article{article, author = {Shichkin, Valentin P. and Antica, Mariastefania}, year = {2022}, pages = {18}, DOI = {10.3389/fimmu.2022.926516}, chapter = {926516}, keywords = {thymus, thymic epithelial cells (TEC), thymic microenvironment, thymus regeneration, T cells, intrathymic regulators, thymic stem cells}, journal = {Frontiers in Immunology}, doi = {10.3389/fimmu.2022.926516}, volume = {13}, issn = {1664-3224}, title = {Key Factors for Thymic Function and Development}, keyword = {thymus, thymic epithelial cells (TEC), thymic microenvironment, thymus regeneration, T cells, intrathymic regulators, thymic stem cells}, chapternumber = {926516} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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