engleski

Genetic sub-structuring of Croatian island populations in a wider southeast-European context- a meta-analysis

Goal was to determine the influence of island population isolation on the sub structuring of the Croatian population, and the influence of regional population groups on the sub structuring of Southeast Europe with regards to basic population genetic statistical parameters calculated using STR locus analysis. Bio-statistical analyzes were performed for a total sample of 2877 unrelated participants of both sexes from the area of Southeastern Europe was analyzed. Nine autosomal STR loci (D3S1358, vWA, FGA, TH01, TPOX, CSF1PO, D5S818, D13S317, D7S82) were analyzed using standard F-statistics and population structure analysis (program STRUCTURE). The total coefficient of genetic differentiation of Croatian subpopulations calculated by the FST method is higher at the level of the Croatian population (0.005) than at the level of Southeast Europe (0.002). In the population of Croatia, the subpopulation of the island of Vis shows the most pronounced separation, and in the population of Southeast Europe the population of Albanians from Kosovo, then the populations of Croatia, Bosnia and Herzegovina and Hungary. The established higher structure of Croatian subpopulations in relation to the populations of Southeast Europe suggests the existence of a certain degree of genetic isolation, most likely due to the influence of endogamy within rural island populations. The total genetic differentiation coefficient of Croatian subpopulations calculated by the FST method is higher at the level of the Croatian population (0.005) than at the level of Southeast Europe (0.002). The established higher structure of Croatian subpopulations in relation to Southeast Europe suggest the existence of a certain degree of genetic isolation, most likely due to the influence of endogamy within rural island populations.

Genetic sub-structuring ; STR ; Southeastern Europe ; Croatian island isolates

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