engleski

HRMS characterization of doxazosin degradation products generated by gamma irradiation

Over the last decade, pharmaceuticals have attracted increased attention as emerging contaminants due to their presence in natural waters and potential negative effect on the environment. It is known that conventional wastewater treatment processes are unable to completely remove them from wastewater, therefore there is a need for developing new and more effective processes, such as oxidation by generating highly reactive radicals by photochemical or ionizing radiation. Several studies indicated that gamma irradiation is a successful and cost-effective method of degradation for a wide variety of pharmaceuticals. Doxazosin (DOX) is a selective alpha blocker, used in the treatment of hypertension. Due to its widespread use, there is a possibility of its occurrence in aquatic environment. Therefore, development of suitable degradation method is of great importance. Photolytic and photocatalytic degradation od doxazosin was previously studied, and main degradation products were characterized. In this work, degradation of doxazosin by gamma irradiation in the presence of air and N2O was studied. High-resolution quadrupole time-of-flight (QTOF) mass spectrometry was used for detection and characterization of degradation products. Structures of degradation products were determined based on MS and MSMS spectra, and degradation pathways under different conditions were proposed.

doxazosin ; gamma irradiation ; mass spectrometry

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