engleski

Utjecaj ispune 3D-tiskanih tableta na profile oslobađanja dronedaron-hidroklorida

3D printing technology is nowadays widely applied in pharmaceutical industry. A great number of formulations, including those containing multiple drugs, different geometry and release characteristics, have already been made leading to the concept of personalized medicine. The aim of this research was to produce tablets that contain dronedarone hydrochloride (DNR), with different tablet infill using fused deposition modeling and drug-loaded self-produced filaments. Two different blends containing dronedarone hydrochloride, polyvinyl alcohol and excipients such as polyethylene glycol or sorbitol, were made. Filaments were produced by hot melt extrusion at 170 °C, their diameter was measured and the content of DNR was determined. Fused deposition modeling was used for 3D printing of tablets with different material infill from the obtained filaments. Release profiles of DNR from manufactured tablets were obtained using in vitro tests. The results indicate that the filament made out of the blend that contains polyethylene glycol have smooth surface, slighter deviation from the target filament diameter (1, 75 mm) and from the expected DNR content (10 wt.%) than the filament containing sorbitol. The tablets made from polyethylene glycol containing filament have a compact structure that contributes to uniform release of DNR during 28 hours. Research shows that material infill have influence on release kinetic of DNR and that different tablet infills can be used to provide different doses from single filament. Release profiles were described using Hixson- Crowell model. The equation is often used to describe release from systems where the dissolution occurs in planes that are parallel to the drug surface and where the tablet dimensions diminish proportionally keeping initial geometrical form constant. Adjusted values of the coefficient of determination showed applicability of the model for tablets with 100% and 75% infill.

3D-tisak, inspitivanja in vitro, dronedaron-hidroklorid, kinetički modeli

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