Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1203399

Single moderate traumatic brain injury in mice induces transient acute changes in the cortical iNOS expression and its cytoplasmic co- localization with TDP-43


Janković, Tamara; Gržeta, Nika; Dolenec, Petra; Križ, Jasna; Pilipović, Kristina
Single moderate traumatic brain injury in mice induces transient acute changes in the cortical iNOS expression and its cytoplasmic co- localization with TDP-43 // Inflammation and Proteinopathy in ALS/FTD Spectrum Disorder
Rijeka, Hrvatska, 2022. str. 25-26 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1203399 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Single moderate traumatic brain injury in mice induces transient acute changes in the cortical iNOS expression and its cytoplasmic co- localization with TDP-43

Autori
Janković, Tamara ; Gržeta, Nika ; Dolenec, Petra ; Križ, Jasna ; Pilipović, Kristina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Inflammation and Proteinopathy in ALS/FTD Spectrum Disorder / - , 2022, 25-26

Skup
Inflammation and Proteinopathy in ALS/FTD Spectrum Disorder

Mjesto i datum
Rijeka, Hrvatska, 30.06.2022. - 03.07.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Cortex ; Inducible nitric oxide synthase ; Hippocampus ; Traumatic brain injury

Sažetak
Introduction: Traumatic brain injury (TBI) occurs as a consequence of mechanical injury to the brain and is considered to be the leading cause of death and disability in young individuals. Inflammation, one of the secondary injury pathophysiological processes, contributes to posttraumatic brain damage and lifelong cognition and memory impairments. Inducible nitric oxide synthase (iNOS) is a cytoplasmic enzyme that forms the signalling molecule nitric oxide involved in neuroinflammation. In TBI, it has been also shown that mislocalization of TAR DNA-binding protein 43 (TDP-43) contributes to post-injury pathology. We investigated acute changes in the iNOS expression following single moderate TBI in wild-type mice in different brain regions and its colocalization with TDP-43. Materials/Methods: Single moderate lateral fluid percussion injury was induced over the left parietal cortex of the male adult C57BL/J mice. Animals were sacrificed one or three days after TBI and their brains were prepared for Western blot or immunohistological analyses. Animals of the control group were sacrificed 1 day after the sham injury procedure. Results: An increase in the iNOS expression was observed in the ipsilateral cortex one day after the brain trauma. In the tested time points, changes in the iNOS expression were not detected in the ipsilateral hippocampus and contralateral cortex, and hippocampus of traumatized animals. Also, a colocalization of iNOS and TDP-43 in the cytoplasm was observed in the most damaged part of the ipsilateral cortex one day after TBI. Conclusions: Transient acute changes in the proinflammatory marker iNOS in the ipsilateral cortex are induced by single moderate brain trauma. Cytoplasmic colocalization of iNOS and TDP-43 in the most damaged part of the ipsilateral cortex suggests the interconnection of these proteins. This work was supported by the University of Rijeka, Croatia, project number uniri-biomed-18-199 to K.P.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekti:
NadSve-uniri-biomed-18-199 - Molekularni mehanizmi neurodegeneracije u traumatskoj ozljedi mozga: uloga TAR DNA-vezujućeg proteina 43 (Pilipović, Kristina, NadSve ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka


Citiraj ovu publikaciju:

Janković, Tamara; Gržeta, Nika; Dolenec, Petra; Križ, Jasna; Pilipović, Kristina
Single moderate traumatic brain injury in mice induces transient acute changes in the cortical iNOS expression and its cytoplasmic co- localization with TDP-43 // Inflammation and Proteinopathy in ALS/FTD Spectrum Disorder
Rijeka, Hrvatska, 2022. str. 25-26 (poster, međunarodna recenzija, sažetak, znanstveni)
Janković, T., Gržeta, N., Dolenec, P., Križ, J. & Pilipović, K. (2022) Single moderate traumatic brain injury in mice induces transient acute changes in the cortical iNOS expression and its cytoplasmic co- localization with TDP-43. U: Inflammation and Proteinopathy in ALS/FTD Spectrum Disorder.
@article{article, author = {Jankovi\'{c}, Tamara and Gr\v{z}eta, Nika and Dolenec, Petra and Kri\v{z}, Jasna and Pilipovi\'{c}, Kristina}, year = {2022}, pages = {25-26}, keywords = {Cortex, Inducible nitric oxide synthase, Hippocampus, Traumatic brain injury}, title = {Single moderate traumatic brain injury in mice induces transient acute changes in the cortical iNOS expression and its cytoplasmic co- localization with TDP-43}, keyword = {Cortex, Inducible nitric oxide synthase, Hippocampus, Traumatic brain injury}, publisherplace = {Rijeka, Hrvatska} }
@article{article, author = {Jankovi\'{c}, Tamara and Gr\v{z}eta, Nika and Dolenec, Petra and Kri\v{z}, Jasna and Pilipovi\'{c}, Kristina}, year = {2022}, pages = {25-26}, keywords = {Cortex, Inducible nitric oxide synthase, Hippocampus, Traumatic brain injury}, title = {Single moderate traumatic brain injury in mice induces transient acute changes in the cortical iNOS expression and its cytoplasmic co- localization with TDP-43}, keyword = {Cortex, Inducible nitric oxide synthase, Hippocampus, Traumatic brain injury}, publisherplace = {Rijeka, Hrvatska} }




Contrast
Increase Font
Decrease Font
Dyslexic Font