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Lactogenic and Bifidogenic Effect of Prebiotic Substrates in Innovative Formulations of Food for Special Medical Purposes

Food for Special Medical Purposes (FSMPs) is a new class of therapeutic products, specifically formulated for the dietary management of diseases, disorders or medical conditions of patients. Moreover, recent research pointed out the importance of the gut microbiota on host physiology, which composition can be highly influenced by dietary fiber intake. Therefore, the aim of this study was to examine the lactogenic and bifidogenic effects of different dietary fibers as nutritional supplementation of FSMPs in order to develop new innovative formulations by using mice faeces as a model system. All tested dietary fibers showed a lactogenic effect, which differed depending on dietary fiber applied. The largest increase in bacterial counts expressed as log CFU/mL was determined in the presence of soluble fibers, marked as SF 1, SF2 and SF3, as well as combination of soluble and insoluble fibers marked as CSIF 1 and insoluble fibers namely as IF 1. The highest bifidogenic effect was achieved by dietary fibers of soluble fibers SF 2 and combination of soluble and insoluble fibers CSIF 1. Tested mixtures of dietary fibers showed both lactogenic and bifidogenic effects, resulting out of the synergistic effect of component fibers, which differed from the lactogenic and bifidogenic effects achieved by individual dietary fibers. Further studies will be directed towards the determination of prebiotic effects on faecal microbiota of mice in vivo of dietary fiber mixtures created for different formulations of FSMPs.

dietary fibers ; food for special medical purposes (FSMPs) ; lactogenic and bifidogenic effect ; prebiotic properties

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