engleski

Comparative photo-oxidative degradation of etodolac, febuxostat and imatinib mesylate by UV- C/H2O2 and UV-C/S2O82− processes: Modeling, treatment optimization and biodegradability enhancement

The pharmaceutical contamination in aquatic environment has arisen increasing concern due to its potentially chronic toxicity. In recent years, HO° and SO4°- based advanced oxidation processes (AOPs) have been widely applied in water and wastewater treatments due to their highly efficiency on contaminant removal. Here, the response surface modeling (RSM) was used to investigate the degradation of three typical pharmaceuticals (i.e., etodolac (ETD), febuxostat (FBU) and imatinib mesylate (IMT)) by UV/H2O2 and UV/S2O82− processes. Based on the multiple regression analysis on full factorial design matrix and calculated reaction rate constants, the RSM was built. The experimental rate constants under optimal conditions were quite close to those obtained from the model, implying the good fit of the RSM. In addition, the RSM results indicated that UV/S2O82− process was less sensitive to pH in comparison to the UV/H2O2 process on target contaminant removal. Finally, it showed that UV/S2O82− process was superior to the UV/H2O2 process to on the enhancement of target contaminant biodegradability.

pharmaceuticals ; photo-oxidation ; response surface modeling ; biodegradability

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