engleski

The estimation of linkage disequilibrium decay in Croatian Holstein cattle: potential for genomic selection

The objective of this study was to estimate linkage disequilibrium (LD) in 101 Croatian Holstein cows based on Illumina Bovine50K SNP chip. The average autosomal whole-genome LD (r^2) was 0.16 and for SNPs 100 Kbp apart 0.30. The average within-chromosomal LD ranged from 0.12 for BTA28 to 0.23 for BTA20, with no straightforward relation between chromosome length and r^2. The decay of LD showed an exponential trend with physical distance showing a very steep decay of LD within the first 150 Kbp. The results implicate a sufficient density of the 50K SNP chip for successful implementation of genomic selection (GS) and genome wide association studies (GWAS) in the population of Holstein cattle in Croatia.

Holstein cattle ; linkage disequilibrium ; SNP ; genomic selection

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