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RhBMP6 in autologous blood coagulum with ceramics induces rapid spinal fusion in sheep (CROSBI ID 311109)

Prilog u časopisu | ostalo | međunarodna recenzija

Štoković, Nikola ; Ivanjko, Natalia ; Pećin, Marko ; Smajlovic, Ana ; Ivkić, Niko ; Capak, Hrvoje ; Vrbanac, Zoran ; Vnuk, Drazen ; Matičić, Drazen ; Vukicevic, Slobodan RhBMP6 in autologous blood coagulum with ceramics induces rapid spinal fusion in sheep // Bone reports, 16 (2022), xx-xx. doi: doi.org/10.1016/j.bonr.2022.101326

Podaci o odgovornosti

Štoković, Nikola ; Ivanjko, Natalia ; Pećin, Marko ; Smajlovic, Ana ; Ivkić, Niko ; Capak, Hrvoje ; Vrbanac, Zoran ; Vnuk, Drazen ; Matičić, Drazen ; Vukicevic, Slobodan

engleski

RhBMP6 in autologous blood coagulum with ceramics induces rapid spinal fusion in sheep

Introduction: Osteogrow, an autologous bone graft substitute (ABGS) containing recombinant human Bone Morphogenetic Protein 6 (rhBMP6) within autologous blood coagulum (ABC) as a BMP carrier is a novel therapeutic solution for bone regeneration. Calcium phosphate ceramic particles might be added to Osteogrow to improve the biomechanical properties of implants. Purpose: This study aimed to evaluate Osteogrow with synthetic ceramic particles (Osteogrow C) in the sheep posterolateral spinal fusion (PLF) model. Methods: Osteogrow C implants containing 74-420 μm (n=6) or 500- 1700 μm (n=6) ceramic particles were prepared as follow: lyophilized rhBMP6 (0, 5 mg per implant) was dissolved in water and added to 8 mL of autologous blood withdrawn from the jugular vein and mixed with ceramic particles. Osteoinductive implants were placed between L4-L5 transverse processes of sheep (Ovis Aries, Merinolaandschaf breed, aged 4-5 years). Spinal fusion was assessed 9 weeks after surgery by in vivo CT scanning. Animals were terminated 14 weeks following implantation to further evaluate the spinal fusion outcome by microCT, biomechanical testing, and histology. The study was approved by the Institutional and National Ethics Committees Results: Osteogrow C implants with both 74-420 and 500-1700 μm ceramic particles induced formation of bone and fusion with transverse processes 9 weeks following implantation as evidenced by in vivo CT scans. Ex vivo microCT, histological and biomechanical analyses confirmed these findings and revealed that newly formed bone was completely integrated with native transverse processes providing biomechanically competent fusion. Conclusions: Osteogrow C implants induce rapid spinal fusion in the sheep PLF model and provide a possible therapeutic solution for patients with degenerative disease of the spine.

rhBMP6 ; ceramics ; spinal fusion ; rapid ; sheep

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Podaci o izdanju

16

2022.

xx-xx

objavljeno

2352-1872

doi.org/10.1016/j.bonr.2022.101326

Povezanost rada

Temeljne medicinske znanosti, Veterinarska medicina

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