Effects of IV remifentanil (Remi) on the discharge of canine pontine respiratory group (PRG) neurons in the parabrachial complex (PB) (CROSBI ID 719380)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Prkic, Ivana ; Mustapic, Sanda ; Radocaj, Tomislav ; Stucke, Astrid G. ; Stuth, Eckehard A. ; Hopp, Francis A. ; Zuperku, Edward J.
engleski
Effects of IV remifentanil (Remi) on the discharge of canine pontine respiratory group (PRG) neurons in the parabrachial complex (PB)
Mu-opioids at clinical doses produce bradypnea, which is reversed by microinjection of naloxone into the pontine PB. We studied the effects of the mu-opioid agonist Remi (IV) on PRG neuron discharge patterns in decerebrate, vagotomized, ventilated, paralyzed dogs. A NeuroNexus 16- electrode microprobe was used to record from multiple PRG neurons before, during and after IV Remi. Histograms (CTHs) of PRG discharge patterns, triggered from the phrenic neurogram (PNG), were used to quantify Remi effects on ten PRG neuron subtypes. Remi (0.5–0.8 mcg/kg/min) increased TI and TE by 21% and 23% respectively, and decreased peak PNG by 33±3%. PRG neurons (n=197) were located 0.5–2 mm caudal to inferior colliculus, 5– 6.5 mm lateral to midline and 2.5–4.5 mm below the dorsal surface. The depression (peak Fn) of all PRG neurons (28±3% ; n=197) was similar among 9 of 10 subtypes, but Edec neurons were more depressed (70±6% ; n=24 ; p<0.001). Magnitude of neuronal depression was not related to control Fn, or changes in TI or TE except for Icon neurons and TI (r = −0.72 ; p<0.001). PRG neurons, except Edec, were less depressed than the peak PNG. Marked depression in PRG Edec neurons may underlie loss of recurrent laryngeal Edec activity. Opioid- induced depression of PRG subtypes coincident with bradypnea is consistent with reduced excitation to medullary rhythm generation. Supported by VA Merit Review Award: 1 I01 BX000721–01.
Mu-opioids ; PRG neuron ; pons
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Podaci o prilogu
1214.4
2013.
objavljeno
10.1096/fasebj.27.1_supplement.1214.4
Podaci o matičnoj publikaciji
John Wiley & Sons
0892-6638
Podaci o skupu
Experimental Biology 2013
poster
20.04.2013-24.04.2013
Boston (MA), Sjedinjene Američke Države
Povezanost rada
Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)