engleski

Apoptosis as a Growth Parameter of Colon Tumors and Hormone Dependent and Independent Tumors

We have analysed stereologically a number of apoptotic bodies in two human tumor models. In the first model we have investigated we found the lowest numeric density of apoptotic bodies in the adenomatous polyps of colon, ihe greater density in adenovillous polyps, and ihe greatest density in colon adenocarcinomas, specially in the Dukes B group. These findings suggested a possible role of apoptosis in the carcinogenesis of colon carcinomas. In the second model we investigated, the numerical and volume density of apoptotic bodies shows the difference in apoptotic celI number among the hormonal dependent and independent tumors. By comparing the cancers of the breast and basaliomas, breast cancers and melanomas, and endometrial carcinomas and melanomas, an important difference was statistically established because in every case (with probability 99%) border value t was P < 0, 01. In the group of the breast cancer, the results showed an outstanding dependence of apoptosis on the trophical hormon. This dependence was noticed based on the inerease of apoptatic cell number in the second half of menstrual cycle, and tumors with negative estrogen receptors. In the group of the endometrial carcinoma that are the tumors of the older age, women in postmenopause, when the downfall of the trophical hormon is clearly present, a higher number of apoptotic cells then in the endometral hyperplasias and the skin tumors had been proved. All these findings are suggesting that a number of tumor apoptotic cells ("apoptotic index") could be eventually a good parameter of tumor growth.

apoptosis; colon tumors

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