engleski

APOPTOSIS IN BENIGN GLIOMAS AND METASTATIC BRAIN TUMORS - PILOT STUDY

Apoptosis is programmed cell death, control mechanism of cell elimination, process with genetic surveillance. It is energy dependent process that can be initiated, inhibited and modified with different exogenic and endogenic factors. In the recent literature there is small number of information about researches on human material and very small number of information about findings of apoptosis in primary tumors of CNS. This work is pilot study of research the apoptosis in pilocytic astrocytoma as prototype of primary benign gIioma and in metastatic brain tumors. It is known that the pilocytic astrocytoma is slowly growing benign glioma (grade I) and we were interested if the control mechanism of the growth of the tumor is in domain of apoptosis. Bioptic material was analyzed histologically in 30 cases and was treated stereologically in order to determine the volume density of apoptotic cells at this moment. The results show that apoptotic cells were not found in the group of pilocytic astrocytoma and that the largest volume density of apoptotic cells was in the group of metastatic brain tumor - type adenocarcinoma and smaller one in the group of metastatic brain tumor - type solid carcinoma.

APOPTOSIS; BENIGN GLIOMAS; METASTATIC BRAIN TUMORS

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