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Pregled bibliografske jedinice broj: 1198440

Three different methods confirmed the association of macro and microelements with cerebrospinal fluid biomarkers of Alzheimer's disease


Mihelčić, Matej; Babić Leko, Mirjana; Jurasović, Jasna; Nikolac Perković, Matea; Španić, Ena; Sekovanić, Ankica; Orct, Tatjana; Zubčić, Klara; Langer Horvat, Lea; Pleić, Nikolina et al.
Three different methods confirmed the association of macro and microelements with cerebrospinal fluid biomarkers of Alzheimer's disease // Xjenza, vol. 10, special issue / Sebu, Cristiana (ur.).
Msida, Malta: Malta Chamber of Scientists, 2022. str. 142-142 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1198440 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Three different methods confirmed the association of macro and microelements with cerebrospinal fluid biomarkers of Alzheimer's disease

Autori
Mihelčić, Matej ; Babić Leko, Mirjana ; Jurasović, Jasna ; Nikolac Perković, Matea ; Španić, Ena ; Sekovanić, Ankica ; Orct, Tatjana ; Zubčić, Klara ; Langer Horvat, Lea ; Pleić, Nikolina ; Kiđemet-Piskač, Spomenka ; Vogrinc, Željka ; Pivac, Nela ; Borovečki, Fran ; Hof, Patrick R. ; Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Xjenza, vol. 10, special issue / Sebu, Cristiana - Msida, Malta : Malta Chamber of Scientists, 2022, 142-142

Skup
8th Mediterranean Neuroscience Conference

Mjesto i datum
Dubrovnik, Hrvatska, 29.5.-02.06.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Alzheimer's disease ; cerebrospinal fluid protein biomarkers ; cognitive impairment ; inductively coupled plasma mass spectroscopy ; machine learning ; metalloids ; metals ; plasma ; principal component analysis ; redescription mining ; trace elements

Sažetak
The homeostasis of metals is altered in the brain of Alzheimer’s disease (AD) patients. It was proposed that changes in metal homeostasis are related to AD pathology. Additionally, metals that are not present in the brain under normal circumstances (such as mercury, lead and cadmium) were associated with AD pathogenesis. The aim of this study was to test if macro and microelements (Li, B, Na, Mg, Al, S, K, Ca, Cr, Fe, Co, Mn, Ni, Cu, Zn, As, Se, Sr, Mo, Cd, Ba, Tl, Pb, and Hg) measured in cerebrospinal fluid (CSF) and plasma of patients with dementia are associated with CSF biomarkers of AD. CSF AD biomarkers reflect pathological changes in AD brain, while the involvement of different metals in AD pathogenesis is still the matter of debate. Macro and microelements were determined by inductively coupled plasma mass spectroscopy (ICP-MS), while CSF biomarkers were measured by enzyme-linked immunosorbent assays (ELISA). Macro and microelements were measured in CSF of 194 subjects and in plasma of 144 subjects (study included overall 125 AD patients, 50 patients with mild cognitive disorder and 19 healthy controls). We used three different statistical methods to test the association of macro and microelements with CSF biomarkers of AD. All three methods (simple correlation and two machine learning algorithms ; redescription mining and principal component analysis [PCA]) demonstrated the association of macro and microelements with CSF biomarkers of AD. Possible explanations for association of macro and microelements with CSF biomarkers of AD await elucidation of their environmental sources or detection of their release from brain tissue due to cell death. Also, these results should be further validated on larger cohorts.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)



POVEZANOST RADA


Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Medicinski fakultet, Zagreb,
Medicinski fakultet, Split


Citiraj ovu publikaciju:

Mihelčić, Matej; Babić Leko, Mirjana; Jurasović, Jasna; Nikolac Perković, Matea; Španić, Ena; Sekovanić, Ankica; Orct, Tatjana; Zubčić, Klara; Langer Horvat, Lea; Pleić, Nikolina et al.
Three different methods confirmed the association of macro and microelements with cerebrospinal fluid biomarkers of Alzheimer's disease // Xjenza, vol. 10, special issue / Sebu, Cristiana (ur.).
Msida, Malta: Malta Chamber of Scientists, 2022. str. 142-142 (poster, međunarodna recenzija, sažetak, znanstveni)
Mihelčić, M., Babić Leko, M., Jurasović, J., Nikolac Perković, M., Španić, E., Sekovanić, A., Orct, T., Zubčić, K., Langer Horvat, L. & Pleić, N. (2022) Three different methods confirmed the association of macro and microelements with cerebrospinal fluid biomarkers of Alzheimer's disease. U: Sebu, C. (ur.)Xjenza, vol. 10, special issue.
@article{article, author = {Mihel\v{c}i\'{c}, Matej and Babi\'{c} Leko, Mirjana and Jurasovi\'{c}, Jasna and Nikolac Perkovi\'{c}, Matea and \v{S}pani\'{c}, Ena and Sekovani\'{c}, Ankica and Orct, Tatjana and Zub\v{c}i\'{c}, Klara and Langer Horvat, Lea and Plei\'{c}, Nikolina and Ki\djemet-Piska\v{c}, Spomenka and Vogrinc, \v{Z}eljka and Pivac, Nela and Borove\v{c}ki, Fran and Hof, Patrick R. and \v{S}imi\'{c}, Goran}, editor = {Sebu, C.}, year = {2022}, pages = {142-142}, keywords = {Alzheimer's disease, cerebrospinal fluid protein biomarkers, cognitive impairment, inductively coupled plasma mass spectroscopy, machine learning, metalloids, metals, plasma, principal component analysis, redescription mining, trace elements}, title = {Three different methods confirmed the association of macro and microelements with cerebrospinal fluid biomarkers of Alzheimer's disease}, keyword = {Alzheimer's disease, cerebrospinal fluid protein biomarkers, cognitive impairment, inductively coupled plasma mass spectroscopy, machine learning, metalloids, metals, plasma, principal component analysis, redescription mining, trace elements}, publisher = {Malta Chamber of Scientists}, publisherplace = {Dubrovnik, Hrvatska} }
@article{article, author = {Mihel\v{c}i\'{c}, Matej and Babi\'{c} Leko, Mirjana and Jurasovi\'{c}, Jasna and Nikolac Perkovi\'{c}, Matea and \v{S}pani\'{c}, Ena and Sekovani\'{c}, Ankica and Orct, Tatjana and Zub\v{c}i\'{c}, Klara and Langer Horvat, Lea and Plei\'{c}, Nikolina and Ki\djemet-Piska\v{c}, Spomenka and Vogrinc, \v{Z}eljka and Pivac, Nela and Borove\v{c}ki, Fran and Hof, Patrick R. and \v{S}imi\'{c}, Goran}, editor = {Sebu, C.}, year = {2022}, pages = {142-142}, keywords = {Alzheimer's disease, cerebrospinal fluid protein biomarkers, cognitive impairment, inductively coupled plasma mass spectroscopy, machine learning, metalloids, metals, plasma, principal component analysis, redescription mining, trace elements}, title = {Three different methods confirmed the association of macro and microelements with cerebrospinal fluid biomarkers of Alzheimer's disease}, keyword = {Alzheimer's disease, cerebrospinal fluid protein biomarkers, cognitive impairment, inductively coupled plasma mass spectroscopy, machine learning, metalloids, metals, plasma, principal component analysis, redescription mining, trace elements}, publisher = {Malta Chamber of Scientists}, publisherplace = {Dubrovnik, Hrvatska} }




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