Polymorphisms within serotonin receptor genes are associated with genetic, cerebrospinal fluid and neuropsychological biomarkers of Alzheimer’s disease (CROSBI ID 718886)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Babić Leko, Mirjana ; Nikolac Perković, Matea ; Španić, Ena ; Švob Štrac, Dubravka ; Pleić, Nikolina ; Vogrinc, Željka ; Gunjača, Ivana ; Klepac, Nataša ; Borovečki, Fran ; Pivac, Nela ; Zemunik, Tatijana ; Hof, Patrick R. ; Šimić, Goran
engleski
Polymorphisms within serotonin receptor genes are associated with genetic, cerebrospinal fluid and neuropsychological biomarkers of Alzheimer’s disease
Decrease in serotonergic transmission throughout the brain is among the earliest pathological changes in Alzheimer’s disease (AD). Serotonergic receptors are also affected in AD. Polymorphisms in genes for serotonin (5HT) receptors were mostly associated with behavioral and psychological symptoms of dementia (BPSD). In this study we aimed to test if individuals carrying different genotypes in 5HTR1B rs13212041, 5HTR2A rs6313 (T102C), 5HTR2C rs3813929 (-795C/T) and 5HTR6 rs1805054 (C267T) polymorphisms have higher risk for development of AD. Study included 115 AD patients and 53 mild cognitive impairment patients with determined cerebrospinal fluid (CSF) AD biomarkers, neuropsychological tests, and apolipoprotein E (APOE) haplotype and 2701 cognitively healthy individuals with determined APOE haplotype. All four analysed polymorphisms of serotonin receptor genes showed the association with either genetic, CSF or neuropsychological biomarkers of AD. Thus, these polymorphisms deserve further investigation as potential genetic biomarkers and therapeutic targets for AD.
Alzheimer's disease ; APOE genotype ; behavioral and psychological symptoms of dementia ; cerebrospinal fluid biomarkers ; cognitive impairment ; neuropsychological testing ; polymorphisms ; receptors ; serotonin
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Podaci o prilogu
141-141.
2022.
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objavljeno
Podaci o matičnoj publikaciji
Xjenza, vol. 10, special issue
Sebu, Cristiana
Msida: Malta Chamber of Scientists
1818-7250
1818-7269
Podaci o skupu
8th Mediterranean Neuroscience Society Conference (MNS)
poster
29.05.2022-02.06.2022
Dubrovnik, Hrvatska