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Pregled bibliografske jedinice broj: 1198388

Interactions of macrozones with their biological receptors


Jednačak, Tomislav; Mikulandra, Ivana; Kapustić, Monika; Kušec, Iva; Smokrović, Kristina; Hošnjak, Ema; Piantanida, Ivo; Košćak, Marta; Zangger, Klaus; Novak, Predrag
Interactions of macrozones with their biological receptors // Magnetic Moments in Central Europe 2022, Joint meeting, Adriatic NMR Conference : Book of Abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena (ur.).
Zagreb: Croatian Chemical Society, 2022. str. 78-78 (poster, nije recenziran, sažetak, znanstveni)


CROSBI ID: 1198388 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Interactions of macrozones with their biological receptors

Autori
Jednačak, Tomislav ; Mikulandra, Ivana ; Kapustić, Monika ; Kušec, Iva ; Smokrović, Kristina ; Hošnjak, Ema ; Piantanida, Ivo ; Košćak, Marta ; Zangger, Klaus ; Novak, Predrag

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Magnetic Moments in Central Europe 2022, Joint meeting, Adriatic NMR Conference : Book of Abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena - Zagreb : Croatian Chemical Society, 2022, 78-78

ISBN
978-953-8334-04-7

Skup
Magnetic Moments in Central Europe 2022

Mjesto i datum
Primošten, Hrvatska, 01-04.06.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
macrolides ; interactions ; biological receptors ; NMR ; fluorescence

Sažetak
Macrolides belong to the largest class of antibiotics and are clinically used for the treatment of upper and lower respiratory tract infections. They inhibit the synthesis of bacterial proteins by reversible binding to the ribosomal 23S RNA at the peptidyl transferase region, which blocks the exiting tunnel for newly synthesized peptides. Despite the fact that new antibiotics have recently been developed, some bacteria have acquired broad resistance, representing a global medical problem, which can only be resolved by the discovery of novel and more potent drugs. It has been reported that linking known macrolides to bioactive thiosemicarbazones resulted with new conjugates, the macrozones, efficient against multidrug resistant strains. On the other hand, some thiosemicarbazones and their metal complexes showed anti-infective, antitumor and anti- inflammatory activity. In this work, we structurally characterized several azithromycin- derived macrozones and their metal complexes. Furthermore, interactions between the macrozones showing excellent in vitro activity and the E. coli ribosome were studied by a combination of NMR methods and fluorescence measurements. Transferred nuclear Overhauser effect (trNOE), saturation transfer difference (STD) and WaterLogsy experiments provided a wealth of information about ligand conformations and binding epitopes. Fluorescence measurements revealed binding constants. The obtained results can serve as a good basis for the design and development of macrolide conjugates with enhanced biological properties.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Farmacija



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-8098 - Makrozoni, novi konjugati makrolidnih antibiotika: Dizajn, priprava i interakcije (Makrozoni/Macrozones) (Novak, Predrag, HRZZ - 2018-01) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

mmce2022.hkd.hr

Citiraj ovu publikaciju:

Jednačak, Tomislav; Mikulandra, Ivana; Kapustić, Monika; Kušec, Iva; Smokrović, Kristina; Hošnjak, Ema; Piantanida, Ivo; Košćak, Marta; Zangger, Klaus; Novak, Predrag
Interactions of macrozones with their biological receptors // Magnetic Moments in Central Europe 2022, Joint meeting, Adriatic NMR Conference : Book of Abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena (ur.).
Zagreb: Croatian Chemical Society, 2022. str. 78-78 (poster, nije recenziran, sažetak, znanstveni)
Jednačak, T., Mikulandra, I., Kapustić, M., Kušec, I., Smokrović, K., Hošnjak, E., Piantanida, I., Košćak, M., Zangger, K. & Novak, P. (2022) Interactions of macrozones with their biological receptors. U: Bregović, N., Namjesnik, D., Novak, P. & Parlov Vuković, J. (ur.)Magnetic Moments in Central Europe 2022, Joint meeting, Adriatic NMR Conference : Book of Abstracts.
@article{article, author = {Jedna\v{c}ak, Tomislav and Mikulandra, Ivana and Kapusti\'{c}, Monika and Ku\v{s}ec, Iva and Smokrovi\'{c}, Kristina and Ho\v{s}njak, Ema and Piantanida, Ivo and Ko\v{s}\'{c}ak, Marta and Zangger, Klaus and Novak, Predrag}, year = {2022}, pages = {78-78}, keywords = {macrolides, interactions, biological receptors, NMR, fluorescence}, isbn = {978-953-8334-04-7}, title = {Interactions of macrozones with their biological receptors}, keyword = {macrolides, interactions, biological receptors, NMR, fluorescence}, publisher = {Croatian Chemical Society}, publisherplace = {Primo\v{s}ten, Hrvatska} }
@article{article, author = {Jedna\v{c}ak, Tomislav and Mikulandra, Ivana and Kapusti\'{c}, Monika and Ku\v{s}ec, Iva and Smokrovi\'{c}, Kristina and Ho\v{s}njak, Ema and Piantanida, Ivo and Ko\v{s}\'{c}ak, Marta and Zangger, Klaus and Novak, Predrag}, year = {2022}, pages = {78-78}, keywords = {macrolides, interactions, biological receptors, NMR, fluorescence}, isbn = {978-953-8334-04-7}, title = {Interactions of macrozones with their biological receptors}, keyword = {macrolides, interactions, biological receptors, NMR, fluorescence}, publisher = {Croatian Chemical Society}, publisherplace = {Primo\v{s}ten, Hrvatska} }




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