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Pregled bibliografske jedinice broj: 1197710

A Lack of GD3 Synthase Leads to Impaired Renal Expression of Connexins and Pannexin1 in St8sia1 Knockout Mice


Meter, Diana; Racetin, Anita; Vukojević, Katarina; Balog, Marta; Ivić, Vedrana; Zjalić, Milorad; Heffer, Marija; Filipović, Natalija
A Lack of GD3 Synthase Leads to Impaired Renal Expression of Connexins and Pannexin1 in St8sia1 Knockout Mice // International journal of molecular sciences, 23 (2022), 11; 6237, 23 doi:10.3390/ijms23116237 (međunarodna recenzija, članak, znanstveni)


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Naslov
A Lack of GD3 Synthase Leads to Impaired Renal Expression of Connexins and Pannexin1 in St8sia1 Knockout Mice

Autori
Meter, Diana ; Racetin, Anita ; Vukojević, Katarina ; Balog, Marta ; Ivić, Vedrana ; Zjalić, Milorad ; Heffer, Marija ; Filipović, Natalija

Izvornik
International journal of molecular sciences (1422-0067) 23 (2022), 11; 6237, 23

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
kidney ; GD3 synthase ; St8sia1 ; connexins ; pannexin 1

Sažetak
The aim of this study was to determine the effects of altered ganglioside composition on the expression of Cx37, Cx40, Cx43, Cx45, and Panx1 in different kidney regions of St8sia1 gene knockout mice (St8sia1 KO) lacking the GD3 synthase enzyme. Experiments were performed in twelve male 6-month-old mice: four wild-type (C57BL/6-type, WT) and eight St8sia1 KO mice. After euthanasia, kidney tissue was harvested, embedded in paraffin wax, and processed for immunohistochemistry. The expression of connexins and Panx1 was determined in different regions of the kidney: cortex (CTX.), outer stripe of outer medulla (O.S.), inner stripe of outer medulla (IN.S.), and inner medulla (IN.MED.). We determined significantly lower expression of Cx37, Cx40, Cx45, and Panx1 in different parts of the kidneys of St8sia1 KO mice compared with WT. The most consistent decrease was found in the O.S. where all markers (Cx 37, 40, 45 and Panx1) were disrupted in St8si1 KO mice. In the CTX. region, we observed decrease in the expression of Cx37, Cx45, and Panx1, while reduced expression of Cx37 and Panx1 was more specific to IN.S. The results of the present study suggest that deficiency of GD3 synthase in St8sia1 KO mice leads to disruption of renal Cx expression, which is probably related to alteration of ganglioside composition.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Biotehnologija



POVEZANOST RADA


Projekti:
HRZZ-HRZZ IP-09-2014 - Patofiziološke posljedice promjene sastava lipidnih splavi (RafTuning) (Heffer, Marija, HRZZ - 2014-09) ( POIROT)
HRZZ-IP-2014-09-2324 - Patofiziološke posljedice promjena sastava lipidnih splavi (RafTuning) (Heffer, Marija, HRZZ - 2014-09) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka,
KBC Split,
Medicinski fakultet, Split,
Medicinski fakultet, Osijek

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com

Citiraj ovu publikaciju:

Meter, Diana; Racetin, Anita; Vukojević, Katarina; Balog, Marta; Ivić, Vedrana; Zjalić, Milorad; Heffer, Marija; Filipović, Natalija
A Lack of GD3 Synthase Leads to Impaired Renal Expression of Connexins and Pannexin1 in St8sia1 Knockout Mice // International journal of molecular sciences, 23 (2022), 11; 6237, 23 doi:10.3390/ijms23116237 (međunarodna recenzija, članak, znanstveni)
Meter, D., Racetin, A., Vukojević, K., Balog, M., Ivić, V., Zjalić, M., Heffer, M. & Filipović, N. (2022) A Lack of GD3 Synthase Leads to Impaired Renal Expression of Connexins and Pannexin1 in St8sia1 Knockout Mice. International journal of molecular sciences, 23 (11), 6237, 23 doi:10.3390/ijms23116237.
@article{article, author = {Meter, Diana and Racetin, Anita and Vukojevi\'{c}, Katarina and Balog, Marta and Ivi\'{c}, Vedrana and Zjali\'{c}, Milorad and Heffer, Marija and Filipovi\'{c}, Natalija}, year = {2022}, pages = {23}, DOI = {10.3390/ijms23116237}, chapter = {6237}, keywords = {kidney, GD3 synthase, St8sia1, connexins, pannexin 1}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms23116237}, volume = {23}, number = {11}, issn = {1422-0067}, title = {A Lack of GD3 Synthase Leads to Impaired Renal Expression of Connexins and Pannexin1 in St8sia1 Knockout Mice}, keyword = {kidney, GD3 synthase, St8sia1, connexins, pannexin 1}, chapternumber = {6237} }
@article{article, author = {Meter, Diana and Racetin, Anita and Vukojevi\'{c}, Katarina and Balog, Marta and Ivi\'{c}, Vedrana and Zjali\'{c}, Milorad and Heffer, Marija and Filipovi\'{c}, Natalija}, year = {2022}, pages = {23}, DOI = {10.3390/ijms23116237}, chapter = {6237}, keywords = {kidney, GD3 synthase, St8sia1, connexins, pannexin 1}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms23116237}, volume = {23}, number = {11}, issn = {1422-0067}, title = {A Lack of GD3 Synthase Leads to Impaired Renal Expression of Connexins and Pannexin1 in St8sia1 Knockout Mice}, keyword = {kidney, GD3 synthase, St8sia1, connexins, pannexin 1}, chapternumber = {6237} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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