engleski

Granular cell tumor in the central nervous system of a ferrt Mustela putorius furo)- a case report

Abstract A granular cell tumor (GCT) in the central nervous system (CNS) of a ferret is a rare finding. In this case a cerebral GCT is described in a 5-year-old castrated female ferret. The animal developed lameness in right hind leg which progreseed to total ataxia. The animal died and a necropsy revealed the mass in the medial to caudal part of the left frontal lobe of the brain. Based on histological and imunohistochemical findings, tumor was diagnosed as granular cell tumor. Immunohistochemically, granular cells were diffusely positive for vimentin and neuron- specific enolase (NSE) and weakly focal reactivity for S-100 protein was seen. Neoplastic cells did not express cytokeratins and glial fibrillary acidic protein (GFAP). Although immunohistochemistry was performed, histogenesis of this tumor remains unsolved and controversial. Sažetak Granularni stanični tumor u središnjem živčanom sustavu tvora (Mustela putorius furo) je rijetka pojava. U ovom slučaju je opisan granularni stanični tumor mozga kod pet godina stare ženke tvora. Životinja je razvila šepavost stražnje desne noge koja je prerasla u potpunu ataksiju. Životinja je uginula i napravljena je obdukcija kojom je otkrivena masa u medijalnom do kaudalnom dijelu lijevog frontalnog režnja mozga. Na temelju histološkog i imunohistokemijskog nalaza, tumor je dijagnosticiran kao granularni stanični tumor. Imunohistokemijski su u ovom slučaju tumorske stanice bile difuzno pozitivne na vimentin i neuron-specifičnu enolazu (NSE), a uočena je slaba fokalna reaktivnost na S-100 protein. Neoplastične stanice nisu eksprimirale citokeratine i glialni fibrilarni kiseli protein (GFAP). Iako je napravljena imunohistokemijska analiza, histogeneza ovog tumora ostaje neutvrđena i kontroverzna.

Brain ; Granular cell tumor ; Ferret (Mustela putorius furo) ; Histopathology ; Immunohistochemistry

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