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Pregled bibliografske jedinice broj: 1197308

Association of the autoantibodies to M-type phospholipase A2 receptor titer with clinical characteristics and outcome of patients with primary membranous nephropathy – 5-year follow up study


Laganović, Mario; Horvatić, Ivica; Bubić, Ivan; Ilić, Mario; Maksimović, Bojana; Kozmar Ana; Vuković Brinar, Ivana; Crnogorac, Matija; Živko, Marijana; Fištrek, Margareta et al.
Association of the autoantibodies to M-type phospholipase A2 receptor titer with clinical characteristics and outcome of patients with primary membranous nephropathy – 5-year follow up study // Acta clinica Croatica, 60 (Suppl. 1) (2021), 71-77 doi:10.20471/acc.2021.60.s1.11 (domaća recenzija, članak, znanstveni)


CROSBI ID: 1197308 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Association of the autoantibodies to M-type phospholipase A2 receptor titer with clinical characteristics and outcome of patients with primary membranous nephropathy – 5-year follow up study

Autori
Laganović, Mario ; Horvatić, Ivica ; Bubić, Ivan ; Ilić, Mario ; Maksimović, Bojana ; Kozmar Ana ; Vuković Brinar, Ivana ; Crnogorac, Matija ; Živko, Marijana ; Fištrek, Margareta ; Jureković, Željka, Galešić Ljubanović, Danica ; Ćorić, Marijana ; Bulimbašić, Stela ; Galešić, Krešimir ; Knotek, Mladen

Izvornik
Acta clinica Croatica (0353-9466) 60 (Suppl. 1) (2021); 71-77

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
membranous nephropathy ; M-type phospholipase A2 receptor ; autoantibodies ; glomerulonephritis

Sažetak
SUMMARY – Introduction: primary membranous nephropathy (pMN) is glomerulopathy caused in the majority of cases by autoantibodies to Phospholipase-A2 receptors (PLA2R-AB). This study aimed to evaluate the clinical course and outcomes of the patients with pMN regarding PLA2R-AB status. Patients and methods: 32 patients (21 males, 11 females) with renal biopsy-proven pMN were included in the study. PLA2R-AB (ELISA method) and outcomes (defined according to KDIGO) were evaluated after 21 and 64 months of follow-up in 28 patients. Results: 19 patients had positive PLA2R-AB (>20 RU/ml) (59.3%), with median titer of 97 (21-1418 RU/ml). The rate of remission in low PLA2R-AB titer group (< 200 RU/ml) after 21 months was significantly higher than in high PLA2R-AB group (> 200 RU/ml) (90% vs. 50%, p=0.045), and after 64 months the difference was not significant (80% vs. 50%, p=0.210). The relapse rate after 64 months was higher in the high PLA2R- AB group (87% vs. 63%). Multivariant linear regression found serum creatinine (ß=0.682, p<0.001) and PLA2R-AB (ß=0.527, p<0.001) as significant predictors for kidney function at the end of follow-up. Conclusion: higher titers of PLA2R-AB are related to worse kidney function outcome, higher 24-hour proteinuria, and a higher number of relapses in patients with pMN.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinička bolnica "Merkur",
Medicinski fakultet, Rijeka,
Medicinski fakultet, Zagreb,
Klinička bolnica "Dubrava",
Klinički bolnički centar Zagreb,
Medicinski fakultet, Osijek,
Klinički bolnički centar Rijeka,
Opća bolnica Dubrovnik

Poveznice na cjeloviti tekst rada:

doi hrcak.srce.hr

Citiraj ovu publikaciju:

Laganović, Mario; Horvatić, Ivica; Bubić, Ivan; Ilić, Mario; Maksimović, Bojana; Kozmar Ana; Vuković Brinar, Ivana; Crnogorac, Matija; Živko, Marijana; Fištrek, Margareta et al.
Association of the autoantibodies to M-type phospholipase A2 receptor titer with clinical characteristics and outcome of patients with primary membranous nephropathy – 5-year follow up study // Acta clinica Croatica, 60 (Suppl. 1) (2021), 71-77 doi:10.20471/acc.2021.60.s1.11 (domaća recenzija, članak, znanstveni)
Laganović, M., Horvatić, I., Bubić, I., Ilić, M., Maksimović, B., Kozmar Ana, Vuković Brinar, I., Crnogorac, M., Živko, M. & Fištrek, M. (2021) Association of the autoantibodies to M-type phospholipase A2 receptor titer with clinical characteristics and outcome of patients with primary membranous nephropathy – 5-year follow up study. Acta clinica Croatica, 60 (Suppl. 1), 71-77 doi:10.20471/acc.2021.60.s1.11.
@article{article, author = {Laganovi\'{c}, Mario and Horvati\'{c}, Ivica and Bubi\'{c}, Ivan and Ili\'{c}, Mario and Maksimovi\'{c}, Bojana and Vukovi\'{c} Brinar, Ivana and Crnogorac, Matija and \v{Z}ivko, Marijana and Fi\v{s}trek, Margareta and \'{C}ori\'{c}, Marijana and Bulimba\v{s}i\'{c}, Stela and Gale\v{s}i\'{c}, Kre\v{s}imir and Knotek, Mladen}, year = {2021}, pages = {71-77}, DOI = {10.20471/acc.2021.60.s1.11}, keywords = {membranous nephropathy, M-type phospholipase A2 receptor, autoantibodies, glomerulonephritis}, journal = {Acta clinica Croatica}, doi = {10.20471/acc.2021.60.s1.11}, volume = {60 (Suppl. 1)}, issn = {0353-9466}, title = {Association of the autoantibodies to M-type phospholipase A2 receptor titer with clinical characteristics and outcome of patients with primary membranous nephropathy – 5-year follow up study}, keyword = {membranous nephropathy, M-type phospholipase A2 receptor, autoantibodies, glomerulonephritis} }
@article{article, author = {Laganovi\'{c}, Mario and Horvati\'{c}, Ivica and Bubi\'{c}, Ivan and Ili\'{c}, Mario and Maksimovi\'{c}, Bojana and Vukovi\'{c} Brinar, Ivana and Crnogorac, Matija and \v{Z}ivko, Marijana and Fi\v{s}trek, Margareta and \'{C}ori\'{c}, Marijana and Bulimba\v{s}i\'{c}, Stela and Gale\v{s}i\'{c}, Kre\v{s}imir and Knotek, Mladen}, year = {2021}, pages = {71-77}, DOI = {10.20471/acc.2021.60.s1.11}, keywords = {membranous nephropathy, M-type phospholipase A2 receptor, autoantibodies, glomerulonephritis}, journal = {Acta clinica Croatica}, doi = {10.20471/acc.2021.60.s1.11}, volume = {60 (Suppl. 1)}, issn = {0353-9466}, title = {Association of the autoantibodies to M-type phospholipase A2 receptor titer with clinical characteristics and outcome of patients with primary membranous nephropathy – 5-year follow up study}, keyword = {membranous nephropathy, M-type phospholipase A2 receptor, autoantibodies, glomerulonephritis} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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