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Association of the autoantibodies to M-type phospholipase A2 receptor titer with clinical characteristics and outcome of patients with primary membranous nephropathy – 5-year follow up study (CROSBI ID 310361)

Prilog u časopisu | izvorni znanstveni rad | domaća recenzija

Laganović, Mario ; Horvatić, Ivica ; Bubić, Ivan ; Ilić, Mario ; Maksimović, Bojana ; Kozmar Ana ; Vuković Brinar, Ivana ; Crnogorac, Matija ; Živko, Marijana ; Fištrek, Margareta et al. Association of the autoantibodies to M-type phospholipase A2 receptor titer with clinical characteristics and outcome of patients with primary membranous nephropathy – 5-year follow up study // Acta clinica Croatica. Supplement, 60 (2021), 1; 71-77. doi: 10.20471/acc.2021.60.s1.11

Podaci o odgovornosti

Laganović, Mario ; Horvatić, Ivica ; Bubić, Ivan ; Ilić, Mario ; Maksimović, Bojana ; Kozmar Ana ; Vuković Brinar, Ivana ; Crnogorac, Matija ; Živko, Marijana ; Fištrek, Margareta ; Jureković, Željka, Galešić Ljubanović, Danica ; Ćorić, Marijana ; Bulimbašić, Stela ; Galešić, Krešimir ; Knotek, Mladen

engleski

Association of the autoantibodies to M-type phospholipase A2 receptor titer with clinical characteristics and outcome of patients with primary membranous nephropathy – 5-year follow up study

Introduction: primary membranous nephropathy (pMN) is glomerulopathy caused in the majority of cases by autoantibodies to Phospholipase-A2 receptors (PLA2R-AB). This study aimed to evaluate the clinical course and outcomes of the patients with pMN regarding PLA2R-AB status. Patients and methods: 32 patients (21 males, 11 females) with renal biopsy-proven pMN were included in the study. PLA2R-AB (ELISA method) and outcomes (defined according to KDIGO) were evaluated after 21 and 64 months of follow-up in 28 patients. Results: 19 patients had positive PLA2R-AB (>20 RU/ml) (59.3%), with median titer of 97 (21-1418 RU/ml). The rate of remission in low PLA2R-AB titer group (< 200 RU/ml) after 21 months was significantly higher than in high PLA2R-AB group (> 200 RU/ml) (90% vs. 50%, p=0.045), and after 64 months the difference was not significant (80% vs. 50%, p=0.210). The relapse rate after 64 months was higher in the high PLA2R- AB group (87% vs. 63%). Multivariant linear regression found serum creatinine (ß=0.682, p<0.001) and PLA2R-AB (ß=0.527, p<0.001) as significant predictors for kidney function at the end of follow-up. Conclusion: higher titers of PLA2R-AB are related to worse kidney function outcome, higher 24-hour proteinuria, and a higher number of relapses in patients with pMN.

membranous nephropathy ; M-type phospholipase A2 receptor ; autoantibodies ; glomerulonephritis

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

60 (1)

2021.

71-77

objavljeno

0353-9474

10.20471/acc.2021.60.s1.11

Povezanost rada

Kliničke medicinske znanosti

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