engleski

Metabolic shift during Chlorella vulgaris and Streptomyces rimosus co- cultivation

Co-culture systems are lately being explored as a potential replacement for monoculturing of various microorganisms in order to enhance the biomass yield, increase synthesis of described and yet unidentified bioactive compounds. Utilization of microalgae-bacteria co- cultivation has been well documented on wastewater treatment and downstream processing such as biomass harvesting. In contrast, very little data is known considering the identification of novel metabolites produced only during co-cultivation. This area of research is of particular interest since most of these compounds have a great potential for medical and biotechnological applications. Streptomycetes are well-known bacterial producers of antibiotics, anticancer and immunosuppressant drugs. Abundantly present in the soil, they are adapted to various ecological niches. The capacity to produce diverse metabolites is a result of their interaction with various organisms. Streptomyces rimosus G7 is specifically known for its ability of oxytetracycline production. Chlorella vulgaris is a model microalgae intensively investigated because of its ability to produce various bioactive compounds beneficial for human health. In this study, oxytetracycline producer S.rimosus and C.vulgaris consortium was investigated in order to determine the most relevant bioprocess parameters showing significant effects on the metabolomic flux of both organisms.

Streptomyces rimosus ; Chlorella vulgaris ; co-cultivation ; bioactive compounds

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