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Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD (CROSBI ID 310217)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Repovečki, Senka ; Nedić Erjavec, Gordana ; Uzun, Suzana ; Tudor, Lucija ; Nikolac Perković, Matea ; Konjevod, Marcela ; Kozumplik, Oliver ; Švob Štrac, Dubravka ; Kovačić Petrović, Zrnka ; Mimica, Ninoslav et al. Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD // Biomolecules, 12 (2022), 5; 736, 18. doi: 10.3390/biom12050736

Podaci o odgovornosti

Repovečki, Senka ; Nedić Erjavec, Gordana ; Uzun, Suzana ; Tudor, Lucija ; Nikolac Perković, Matea ; Konjevod, Marcela ; Kozumplik, Oliver ; Švob Štrac, Dubravka ; Kovačić Petrović, Zrnka ; Mimica, Ninoslav ; Pivac, Nela

engleski

Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD

Post‐traumatic stress disorder (PTSD) is a trauma‐ related disorder. Platelet monoamine oxidase (MAO‐ B) is a peripheral biomarker associated with various symptoms in different psychopathologies, but its role in PTSD or different symptoms in PTSD is not clear. This study elucidated the association between platelet MAO‐B activity and clinical symptoms occurring in PTSD. Platelet MAO‐ B activity was determined in 1053 male Caucasian subjects: 559 war veterans with PTSD (DSM‐5 criteria), 62 combat exposed veterans who did not develop PTSD, and 432 non‐combat exposed healthy controls. Clinical symptoms in PTSD were determined using CAPS and PANSS. Platelet MAO‐B activity, controlled for the effect of smoking, was significantly increased in PTSD with severe versus mild and moderate traumatic symptoms, and was significantly decreased in PTSD subjects with severe versus mild positive, psychotic, and depressive symptoms. This finding was further confirmed with reduced platelet MAO‐B activity in PTSD veterans with severe versus mild individual items of the PANSS‐depressed, PANSS‐psychotic, and PANSS‐positive subscales. Altered platelet MAO‐B activity, controlled for the possible confounders, was associated with the development and severity of different symptoms occurring in PTSD. These findings confirmed the role of platelet MAO‐B activity as a peripheral marker of various psychopathological symptoms.

PTSD ; platelet MAO‐B activity ; clinical symptoms ; PANSS ; CAPS

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Podaci o izdanju

12 (5)

2022.

736

18

objavljeno

2218-273X

10.3390/biom12050736

Povezanost rada

Kliničke medicinske znanosti, Temeljne medicinske znanosti

Poveznice
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