Synthesis and biological evaluation of novel N- substituted benzimidazole derived Schiff bases (CROSBI ID 718381)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Beč, Anja ; Cindrić, Maja ; Mehić, Emina ; Persoons, Leentje ; Daelemans, Dirk ; Hranjec, Marijana
engleski
Synthesis and biological evaluation of novel N- substituted benzimidazole derived Schiff bases
Nowadays, there is a growing interest in the synthesis of benzimidazole derived Schiff bases, primarily due to the significant biological activities but also due to the fact that they can easily complexes with different types of metals giving the complexes with interesting electronic and biological properties. [1] They are frequently described as optical chemical sensors or chemodosimeters due to their desirable optical properties, where benzimidazole is often incorporated as a functional or electron-accepting unit. The special interest of scientists has been focused to evaluate the Schiff bases as ligands for transition metals since suchlike complexes possess different biological activities including anticancer, antimicrobial, antifungal etc. [2] Target compounds were prepared by conventional reactions of organic synthesis as well as by microwave assisted reactions. Benzimidazole derived Schiff bases were prepared in the reaction of N-substituted 2-aminobenzimidazoles with 4-N, N- dimethylamino-, 2-hydroxy-4-N, N-dimethylamino- and 4-nitrobenzaldehyde. The structures of all newly prepared benzimidazole derived Schiff bases were confirmed by the means of 1H and 13C NMR spectra and elemental analysis. All Schiff bases were tested for their antiproliferative activity in vitro on a panel of human cancer cells as well as for antiviral activity on several chosen viruses.
antiproliferative activity, antiviral activity, benzimidazoles, cytotoxicity, Schiff bases
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Podaci o prilogu
38-38.
2022.
objavljeno
Podaci o matičnoj publikaciji
8th ICNTC BOOK OF ABSTRACTS
ŞAKAR DAŞDAN, Dolunay
online: ICNTC Secretariat
978-605-73406-0-3
Podaci o skupu
8th International Conference On New Trends In Chemistry
poster
16.05.2022-18.05.2022
Famagusta, Cipar