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Pregled bibliografske jedinice broj: 1196127

Cytotoxicity of nanomixture: Combined action of silver and plastic nanoparticles on immortalized human lymphocytes


Ilić, Krunoslav; Krce, Lucija; Rodriguez-Ramos, Jorge; Rico, Felix; Kalčec, Nikolina; Aviani, Ivica; Turčić, Petra; Pavičić, Ivan; Vinković Vrček, Ivana
Cytotoxicity of nanomixture: Combined action of silver and plastic nanoparticles on immortalized human lymphocytes // Journal of trace elements in medicine and biology, 73 (2022), 127004, 12 doi:10.1016/j.jtemb.2022.127004 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1196127 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cytotoxicity of nanomixture: Combined action of silver and plastic nanoparticles on immortalized human lymphocytes

Autori
Ilić, Krunoslav ; Krce, Lucija ; Rodriguez-Ramos, Jorge ; Rico, Felix ; Kalčec, Nikolina ; Aviani, Ivica ; Turčić, Petra ; Pavičić, Ivan ; Vinković Vrček, Ivana

Izvornik
Journal of trace elements in medicine and biology (0946-672X) 73 (2022); 127004, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Silver Polystyrene Nanoparticles Jurkat cells Cytotoxicity Uptake Oxidative stress

Sažetak
Background Silver nanoparticles (AgNP) are one of the most commercialized types of nanomaterials, with a wide range of applications owing to their antimicrobial activity. They are particularly important in hospitals and other healthcare settings, where they are used to maintain sterility of surfaces, textiles, catheters, medical implants, and more. However, AgNP can not only harm bacteria, but also damage mammalian cells and tissue. While the potential toxicity of AgNP is an understood risk, there is a lack of data on their toxicity in combination with polymeric materials, especially plastic nanoparticles such as polystyrene nanoparticles (PSNP) that can be released from surfaces of polystyrene devices during their medical use. Aim This study aimed to investigate combined effect of AgNP and nanoplastics on human immune response. Methods Cells were treated with a range of PSNP and AgNP concentrations, either applied alone or in combination. Cytotoxicity, induction of apoptosis, generation of oxidative stress, uptake efficiency, intracellular localization and nanomechanical cell properties were selected as exposure biomarkers. Results Collected experimental data showed that nanomixture induced oxidative stress, apoptosis and mortality of Jurkat cells stronger than its individual components. Cell treatment with AgNP/PSNP mixture also significantly changed cell mechanical properties, evidenced by reduction of cells’ Young Modulus. Conclusion AgNP and PSNP showed additive toxic effects on immortalized human lymphocytes, evidenced by increase in cellular oxidative stress, induction of apoptosis, and reduction of cell stiffness. These results have important implications for using AgNP and PSNP in medical contexts, particularly for long-term medical implants.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija, Biologija, Interdisciplinarne prirodne znanosti, Farmacija



POVEZANOST RADA


Projekti:
MZO-N/A - Mehanizam hormonalnih učinaka tipičnih zagađivača okoliša (EMERGETOX) (Vinković Vrček, Ivana, MZO - Natječaj za prijavu znanstveno-istraživačkih projekata velikih razmjera u okviru zajedničkoga hrvatsko-kineskog financiranja istraživačkih projekata Ministarstva znanosti i obrazovanja) ( POIROT)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Ilić, Krunoslav; Krce, Lucija; Rodriguez-Ramos, Jorge; Rico, Felix; Kalčec, Nikolina; Aviani, Ivica; Turčić, Petra; Pavičić, Ivan; Vinković Vrček, Ivana
Cytotoxicity of nanomixture: Combined action of silver and plastic nanoparticles on immortalized human lymphocytes // Journal of trace elements in medicine and biology, 73 (2022), 127004, 12 doi:10.1016/j.jtemb.2022.127004 (međunarodna recenzija, članak, znanstveni)
Ilić, K., Krce, L., Rodriguez-Ramos, J., Rico, F., Kalčec, N., Aviani, I., Turčić, P., Pavičić, I. & Vinković Vrček, I. (2022) Cytotoxicity of nanomixture: Combined action of silver and plastic nanoparticles on immortalized human lymphocytes. Journal of trace elements in medicine and biology, 73, 127004, 12 doi:10.1016/j.jtemb.2022.127004.
@article{article, author = {Ili\'{c}, Krunoslav and Krce, Lucija and Rodriguez-Ramos, Jorge and Rico, Felix and Kal\v{c}ec, Nikolina and Aviani, Ivica and Tur\v{c}i\'{c}, Petra and Pavi\v{c}i\'{c}, Ivan and Vinkovi\'{c} Vr\v{c}ek, Ivana}, year = {2022}, pages = {12}, DOI = {10.1016/j.jtemb.2022.127004}, chapter = {127004}, keywords = {Silver Polystyrene Nanoparticles Jurkat cells Cytotoxicity Uptake Oxidative stress}, journal = {Journal of trace elements in medicine and biology}, doi = {10.1016/j.jtemb.2022.127004}, volume = {73}, issn = {0946-672X}, title = {Cytotoxicity of nanomixture: Combined action of silver and plastic nanoparticles on immortalized human lymphocytes}, keyword = {Silver Polystyrene Nanoparticles Jurkat cells Cytotoxicity Uptake Oxidative stress}, chapternumber = {127004} }
@article{article, author = {Ili\'{c}, Krunoslav and Krce, Lucija and Rodriguez-Ramos, Jorge and Rico, Felix and Kal\v{c}ec, Nikolina and Aviani, Ivica and Tur\v{c}i\'{c}, Petra and Pavi\v{c}i\'{c}, Ivan and Vinkovi\'{c} Vr\v{c}ek, Ivana}, year = {2022}, pages = {12}, DOI = {10.1016/j.jtemb.2022.127004}, chapter = {127004}, keywords = {Silver Polystyrene Nanoparticles Jurkat cells Cytotoxicity Uptake Oxidative stress}, journal = {Journal of trace elements in medicine and biology}, doi = {10.1016/j.jtemb.2022.127004}, volume = {73}, issn = {0946-672X}, title = {Cytotoxicity of nanomixture: Combined action of silver and plastic nanoparticles on immortalized human lymphocytes}, keyword = {Silver Polystyrene Nanoparticles Jurkat cells Cytotoxicity Uptake Oxidative stress}, chapternumber = {127004} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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