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The effect of PARP inhibitors in homologous recombination proficient ovarian cancer: meta- analysis (CROSBI ID 310044)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Skelin, Marko ; Šarčević, David ; Lešin Gaćina, Dina ; Mucalo, Iva ; Dilber, Ivo ; Javor, Eugen The effect of PARP inhibitors in homologous recombination proficient ovarian cancer: meta- analysis // Journal of chemotherapy, 34 (2023), 4; 1-8. doi: 10.1080/1120009X.2022.2073161

Podaci o odgovornosti

Skelin, Marko ; Šarčević, David ; Lešin Gaćina, Dina ; Mucalo, Iva ; Dilber, Ivo ; Javor, Eugen

engleski

The effect of PARP inhibitors in homologous recombination proficient ovarian cancer: meta- analysis

BRCA1/2 mutations and homologous recombination deficiency (HRD) predispose to increased sensitivity to poly(ADP-ribose)polymerase (PARP) inhibitor treatment. Our aim was to evaluate the PARP inhibitors effect on progression free survival (PFS) in a subpopulation with homologous recombination proficient status (HRD-BRCA-). A systematic literature search was performed for all studies reporting on the effect of PARP inhibitors regarding PFS in the HRD-BRCA- subpopulation, in patients with epithelial ovarian, tubal or primary peritoneal cancers (EOC). Five studies were included, enrolling a population of 3413 patients, with 1070 of them being HRD-BRCA-. PARP inhibitors were effective in the treatment of EOC, regardless of HRD and BRCA status or line of therapy. The estimated pooled effect hazard ratio (HR), assessing PFS for PARP inhibitors compared with control, was 0.76 (95% CI: 0.65–0.88, I2 = 46%) in the HRD-BRCA- subpopulation. Comparing both subpopulations with HRD positive status (HRD+ BRCA+, HRD+ BRCA-) versus the HRD-BRCA- subpopulation, we have found statistically significant differences in the effect on PFS (P < 0.05 for every interaction test) favouring HRD positive subpopulations (HRD+ BRCA+, HRD+ BRCA-). In the HRD-BRCA- subpopulation of patients, PARP inhibitors used as the second- or later-line of therapy showed more pronounced effect then when given as first line treatment (P = 0.04). Treatment of EOC with PARP inhibitors showed a significant effect regarding PFS in the HRD-BRCA- subpopulation, although a much higher benefit was evident for patients with HRD+ status (HRD+ BRCA+ and HRD+ BRCA-). In the HRD- subpopulation second line PARP inhibitor treatment showed greater benefit compared to first line PARP inhibitor treatment.

PARP inhibitors ; Homologous recombination deficiency ; BRCA genes ; Ovarian cancer

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Podaci o izdanju

34 (4)

2023.

1-8

objavljeno

1120-009X

1973-9478

10.1080/1120009X.2022.2073161

Povezanost rada

Farmacija, Kliničke medicinske znanosti

Poveznice
Indeksiranost