engleski

A case of macrophagic myofasciitis in a girl with developmental delay

Macrophagic myofasciitis (MMF) is a localized inflammatorymyopathy characterized by infiltration of epimysium, perimy-sium, and endomysium by periodic acid-Schiff stain (PAS)positive macrophages, which contain ultrastructural cytoplas-mic aluminum inclusions.1, 2It is considered to be a localizedimmunological reaction to aluminum used as an adjuvant incertain vaccines.2Macrophagic myofasciitis was firstdescribed in France in 1998, in adult patients with systemicsymptoms such as asthenia, diffuse myalgia, and arthralgia.1In pediatric patients, MMF was described later and in fewercases than in adults, mostly in children in the first few yearsof life, with developmental delay, hypotonia, hyper-CK-emia, lactacidemia, epilepsy, and so forth. There seems to be geneticsusceptibility for developing MMF following vaccination.3While MMF is considered to cause systemic symptoms inadults, 2the clinical presentation of MMF in pediatric patients, if any, remains unclear

aluminum, developmental disability, macrophagic myofasciitis, vaccine

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