engleski

Ki 67 - ANTIGEN IN CHOROID PLEXUS PAPILLOMAS AND CARCINOMAS

Reactivity of Ki 67-antigen was tested in six choroid plexus tumours (three papillomas and three carcinomas) in purpose to evaluate the proliferative potential of each tumour. All evaluated tumours were diagnosed in male children ageing from few months to 12 years except one papilloma which was diagnosed in 23 years old female. Retrospective immunohistochemical characterisation and evaluation of the proliferative potential in this three papillomas and three carcinomas of choroid plexus was performed by reaction on Ki67 - antigen using Strept ABC complex/HRP duet visualisation system method. DAKO Rabbit Anti - Human Ki 67-antigen on the paraffm sections was used. The purpose of this evaluation was to determine and to quantify the proliferative potential in each papilloma and also to compare the proliferative potential of papillomas in relation to carcinomas. Our results show the existence of significant differences in the number of positive immunoreactive cells within choroid plexus papillomas and especially choroid plexus carcinomas. Quantitative differences of Ki 67 - antigen nuclear reactivity may prove as useful clinical indicator for prognosis of the progression and recurrence of choroid plexus tumours.

Ki 67 - ANTIGEN; PAPILLOMAS; CARCINOMAS

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