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CARCINOSARCOMA OF THE URINARY BLADER: A CASE REPORT

We report a case of carcinosarcoma of the urinary bladder in a 72 years old male patient. The patient presented with painless, intermittent hematuria lasting for three months. Clinical examination revealed a (arge, bulky, partially necrotic, tumours mass involving the whole cavity of urinary bladder. Pathologic analysis of transurethrally resected tissue revealed a tumour composed of both carcinomatous and sarcomatous component. The tumour was predominantly composed of moderately to poorly differentiated, atypical transitional epithelial cells forming nests and islands infiltrating submucosa and muscu(ar layer. Between these nests, areas of abnormal cartilage suggesting chondrosarcoma were observed. Immunohistochemical analysis showed positive reaction with anti-cytokeratin antibodies and epithelial membrane antigen in areas of epithelial differentiation and positivity for S-100 protein and vimentin in areas of atypical cartilage. The patient underwent total cystoprostatectomy. The urinary bladder was completely infiltrated with whitish, partially necrotic tumorous tissue, measuring 10 cm in largest diameter. Pathohistologic analysis was consistent with previous findings. In the bladder wall, a diverticulum measuring 3 cm in largest diameter filled with tumours tissue was observed. Histologic analysis revealed tumours tissue showing only epithelial difterentiation. The patient developed recurrence 6 months after the initial presentation and was treated by surgery.

CARCINOSARCOMA; URINARY BLADER

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