engleski

ENDOCERVICAL CARCINOMA METASTATIC TO A "SYMPLASTIC" MYOMA

Metastasis of cervical carcinoma in uterine leiomyoma is a rare event, and it was seldom reported about. Recently, we have observed one unusual case of invasive cervical carcinoma spreading into the endocervically sited leiomyoma, that was histologically confirmed as atypical (or simplastic) leiomyoma. We could not find any data in the available literature concerning this matter. We report a case of a 74 years old patient who underwent surgery due to cervical carcinoma, presented at stage Ib. Surgical specimen showed infiltrative tumour of the cervix, measuring I, Scm in greatest diameter and three solid, firm, white, sharply circumscribed nodules. Two of the nodules were intramural, up to 3 cm in greatest diameter, located in body of uterus and were histologically confirmed as leiomyomas with marked hyalinisation. The third nodule was located in the endocervix, close to the infiltrative tumour, measuring 1cm in greatest diameter. Histologically it was composed of bizarre tumour cells. Variation in size and shape, hypercromatic nuclei and multinucleated forms were present, but no increased mitotic activity. Within this tumour small solid nests of atypical epithelial cells resembling those in cervical carcinoma were found. An extensive immunohistochemical examination (pancytokeratin, cytokeratin 10/13, desmin, PCNA, Ki-67 and p53 antibodies) was provided, and the given results were discussed in the scope of different proliferation potential of both tumours.

ENDOCERVICAL CARCINOMA

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