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Pregled bibliografske jedinice broj: 1195665

Immunohistochemical expression of NEDD9, E-cadherin and γ-catenin and their prognostic significance in pancreatic ductal adenocarcinoma (PDAC)


Radulović , Petra; Krušlin , Božo
Immunohistochemical expression of NEDD9, E-cadherin and γ-catenin and their prognostic significance in pancreatic ductal adenocarcinoma (PDAC) // Bosnian journal of basic medical sciences, 18 (2018), 246-251 (domaća recenzija, članak, znanstveni)


CROSBI ID: 1195665 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Immunohistochemical expression of NEDD9, E-cadherin and γ-catenin and their prognostic significance in pancreatic ductal adenocarcinoma (PDAC)

Autori
Radulović , Petra ; Krušlin , Božo

Izvornik
Bosnian journal of basic medical sciences (1512-8601) 18 (2018); 246-251

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Immunohistochemical expression , ductal adenocarcinoma

Sažetak
Extensive research is being conducted to identify novel diagnostic, predictive and prognostic biomarkers for pancreatic ductal adenocarcinoma (PDAC), as only a few markers have been routinely used so far with limited success. Our aim was to assess the expression of neural precursor cell expressed developmentally down-regulated protein 9 (NEDD9), E-cadherin, and γ-catenin in PDAC in relation to clinicopathological parameters and patient survival. We also investigated if there is a correlation of NEDD9 expression with E-cadherin or γ-catenin. The protein expression was determined by immunohistochemistry in 61 PDAC and 61 samples of normal pancreatic tissue. The log rank test and Kaplan-Meier survival curve were used for survival analysis. E-cadherin and γ-catenin expressions were reduced in PDAC, and completely retained in normal pancreatic tissue. Expression of NEDD9 was significantly increased in PDAC (strong expression in 78.7% of cases and moderate in 21.3%) and reduced in normal pancreatic tissue (strong positivity in 45.9% of cases, moderate in 31.1%, and weak in 23%). There was a positive correlation between reduced E-cadherin and γ-catenin expression in PDAC (p = 0.015). The loss or reduced expression of E-cadherin had a negative impact on patient survival (p = 0.020). A negative correlation between E-cadherin expression and tumor grade was also observed (p = 0.011). Decreased E-cadherin expression was more common in male patients with PDAC (81.3% vs. 60% for females, p = 0.005). γ-catenin and NEDD9 expressions were not statistically correlated with tumor stage and grade, gender, nor with patient survival. Our results support the role of NEDD9, E-cadherin and γ-catenin proteins in PDAC, but further research should clarify in detail their mechanism of action in pancreatic cancer.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
MZOS-108-1081870-1884 - Razvojna neuropatologija genetskih malformacija moždane kore čovjeka (Krušlin, Božo, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice"

Profili:

Avatar Url Božo Krušlin (autor)

Avatar Url Petra Radulović (autor)


Citiraj ovu publikaciju:

Radulović , Petra; Krušlin , Božo
Immunohistochemical expression of NEDD9, E-cadherin and γ-catenin and their prognostic significance in pancreatic ductal adenocarcinoma (PDAC) // Bosnian journal of basic medical sciences, 18 (2018), 246-251 (domaća recenzija, članak, znanstveni)
Radulović , P. & Krušlin , B. (2018) Immunohistochemical expression of NEDD9, E-cadherin and γ-catenin and their prognostic significance in pancreatic ductal adenocarcinoma (PDAC). Bosnian journal of basic medical sciences, 18, 246-251.
@article{article, author = {Radulovi\'{c}, Petra and Kru\v{s}lin, Bo\v{z}o}, year = {2018}, pages = {246-251}, keywords = {Immunohistochemical expression , ductal adenocarcinoma}, journal = {Bosnian journal of basic medical sciences}, volume = {18}, issn = {1512-8601}, title = {Immunohistochemical expression of NEDD9, E-cadherin and γ-catenin and their prognostic significance in pancreatic ductal adenocarcinoma (PDAC)}, keyword = {Immunohistochemical expression , ductal adenocarcinoma} }
@article{article, author = {Radulovi\'{c}, Petra and Kru\v{s}lin, Bo\v{z}o}, year = {2018}, pages = {246-251}, keywords = {Immunohistochemical expression , ductal adenocarcinoma}, journal = {Bosnian journal of basic medical sciences}, volume = {18}, issn = {1512-8601}, title = {Immunohistochemical expression of NEDD9, E-cadherin and γ-catenin and their prognostic significance in pancreatic ductal adenocarcinoma (PDAC)}, keyword = {Immunohistochemical expression , ductal adenocarcinoma} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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