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Pregled bibliografske jedinice broj: 1195664

Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples


de Haan, Noortje; Pučić-Baković, Maja; Novokmet, Mislav; Falck, David; Lageveen-Kammeijer, Guinevere; Razdorov, Genadij; Vučković, Frano; Trbojević-Akmačić, Irena; Gornik, Olga; Hanić, Maja et al.
Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples // Glycobiology, 32 (2022), cwac026, 13 doi:10.1093/glycob/cwac026 (međunarodna recenzija, pregledni rad, znanstveni)


CROSBI ID: 1195664 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples

Autori
De Haan, Noortje ; Pučić-Baković, Maja ; Novokmet, Mislav ; Falck, David ; Lageveen-Kammeijer, Guinevere ; Razdorov, Genadij ; Vučković, Frano ; Trbojević-Akmačić, Irena ; Gornik, Olga ; Hanić, Maja ; Wuhrer, Manfred ; Lauc, Gordan ; the The Human Glycome Project

Izvornik
Glycobiology (0959-6658) 32 (2022); Cwac026, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Glycomics ; Glycoproteomics ; High-throughput ; Mass spectrometry ; Population studies

Sažetak
Glycans expand the structural complexity of proteins by several orders of magnitude, resulting in a tremendous analytical challenge when including them in biomedical research. Recent glycobiological research is painting a picture in which glycans represent a crucial structural and functional component of the majority of proteins, with alternative glycosylation of proteins and lipids being an important regulatory mechanism in many biological and pathological processes. Since interindividual differences in glycosylation are extensive, large studies are needed to map the structures and to understand the role of glycosylation in human (patho)physiology. Driven by these challenges, methods have emerged, which can tackle the complexity of glycosylation in thousands of samples, also known as high-throughput (HT) glycomics. For facile dissemination and implementation of HT glycomics technology, the sample preparation, analysis, as well as data mining, need to be stable over a long period of time (months/years), amenable to automation, and available to non-specialized laboratories. Current HT glycomics methods mainly focus on protein N-glycosylation and allow to extensively characterize this subset of the human glycome in large numbers of various biological samples. The ultimate goal in HT glycomics is to gain better knowledge and understanding of the complete human glycome using methods that are easy to adapt and implement in (basic) biomedical research. Aiming to promote wider use and development of HT glycomics, here, we present currently available, emerging, and prospective methods and some of their applications, revealing a largely unexplored molecular layer of the complexity of life.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Interdisciplinarne prirodne znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekti:
EK-EFRR-KK.01.2.1.02.0321 - Razvoj personaliziranog dijagnostičkog alata za prevenciju i liječenje kardiometaboličkih bolesti (CardioMetabolic) (Lauc, Gordan, EK - Povećanje razvoja novih proizvoda i usluga koji proizlaze iz aktivnosti istraživanja i razvoja – faza II) ( POIROT)
EK-EFRR-KK.01.2.2.03.0006 - Centar kompetencija u molekularnoj dijagnostici (CEKOM) (Knjaz, Damir; Lauc, Gordan; Vugrek, Oliver; Polašek, Ozren, EK - KK.01.2.2.03) ( POIROT)
EK-KF-KK.01.1.1.01.0010 - Znanstveni centar izvrsnosti za personaliziranu brigu o zdravlju (ZCIPersonHealth) (Secenji, Aleksandar, EK - KK.01.1.1.01) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
GENOS d.o.o.

Poveznice na cjeloviti tekst rada:

doi academic.oup.com

Citiraj ovu publikaciju:

de Haan, Noortje; Pučić-Baković, Maja; Novokmet, Mislav; Falck, David; Lageveen-Kammeijer, Guinevere; Razdorov, Genadij; Vučković, Frano; Trbojević-Akmačić, Irena; Gornik, Olga; Hanić, Maja et al.
Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples // Glycobiology, 32 (2022), cwac026, 13 doi:10.1093/glycob/cwac026 (međunarodna recenzija, pregledni rad, znanstveni)
De Haan, N., Pučić-Baković, M., Novokmet, M., Falck, D., Lageveen-Kammeijer, G., Razdorov, G., Vučković, F., Trbojević-Akmačić, I., Gornik, O. & Hanić, M. (2022) Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples. Glycobiology, 32, cwac026, 13 doi:10.1093/glycob/cwac026.
@article{article, author = {de Haan, Noortje and Pu\v{c}i\'{c}-Bakovi\'{c}, Maja and Novokmet, Mislav and Falck, David and Lageveen-Kammeijer, Guinevere and Razdorov, Genadij and Vu\v{c}kovi\'{c}, Frano and Trbojevi\'{c}-Akma\v{c}i\'{c}, Irena and Gornik, Olga and Hani\'{c}, Maja and Wuhrer, Manfred and Lauc, Gordan}, year = {2022}, pages = {13}, DOI = {10.1093/glycob/cwac026}, chapter = {cwac026}, keywords = {Glycomics, Glycoproteomics, High-throughput, Mass spectrometry, Population studies}, journal = {Glycobiology}, doi = {10.1093/glycob/cwac026}, volume = {32}, issn = {0959-6658}, title = {Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples}, keyword = {Glycomics, Glycoproteomics, High-throughput, Mass spectrometry, Population studies}, chapternumber = {cwac026} }
@article{article, author = {de Haan, Noortje and Pu\v{c}i\'{c}-Bakovi\'{c}, Maja and Novokmet, Mislav and Falck, David and Lageveen-Kammeijer, Guinevere and Razdorov, Genadij and Vu\v{c}kovi\'{c}, Frano and Trbojevi\'{c}-Akma\v{c}i\'{c}, Irena and Gornik, Olga and Hani\'{c}, Maja and Wuhrer, Manfred and Lauc, Gordan}, year = {2022}, pages = {13}, DOI = {10.1093/glycob/cwac026}, chapter = {cwac026}, keywords = {Glycomics, Glycoproteomics, High-throughput, Mass spectrometry, Population studies}, journal = {Glycobiology}, doi = {10.1093/glycob/cwac026}, volume = {32}, issn = {0959-6658}, title = {Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples}, keyword = {Glycomics, Glycoproteomics, High-throughput, Mass spectrometry, Population studies}, chapternumber = {cwac026} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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