The Importance of Glycosylation in COVID-19 Infection (CROSBI ID 73139)
Prilog u knjizi | izvorni znanstveni rad
Podaci o odgovornosti
Petrović, Tea ; Lauc, Gordan ; Trbojević-Akmačić, Irena
engleski
The Importance of Glycosylation in COVID-19 Infection
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2), is currently one of the major health problems worldwide. SARS-CoV-2 survival and virulence are shown to be impacted by glycans, covalently attached to proteins in a process of glycosylation, making glycans an area of interest in SARS-CoV-2 biology and COVID-19 infection. The SARS-CoV-2 uses its highly glycosylated spike (S) glycoproteins to bind to the cell surface receptor angiotensin-converting enzyme 2 (ACE2) glycoprotein and facilitate host cell entry. Viral glycosylation has wide-ranging roles in viral pathobiology, including mediating protein folding and stability, immune evasion, host receptor attachment, and cell entry. Modification of SARS- CoV-2 envelope membrane with glycans is important in host immune recognition and interaction between S and ACE2 glycoproteins. On the other hand, immunoglobulin G, a key molecule in immune response, shows a distinct glycosylation profile in COVID-19 infection and with increased disease severity. Hence, further studies on the role of glycosylation in SARS-CoV-2 infectivity and COVID- 19 infection are needed for its successful prevention and treatment. This chapter focuses on recent findings on the importance of glycosylation in COVID-19 infection.
COVID-19 ; glycosylation ; SARS-CoV-2 ; S glycoprotein ; viral infection
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Podaci o prilogu
239-264.
objavljeno
10.1007/978-3-030-70115-4_12
Podaci o knjizi
The Role of Glycosylation in Health and Disease
Lauc, Gordan ; Trbojević-Akmačić, Irena
Cham: Springer
2021.
978-3-030-70115-4
Povezanost rada
Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Interdisciplinarne prirodne znanosti, Kemija, Temeljne medicinske znanosti