engleski

Predictive power of KI 67 antigen expression in uveal melanomas

Uveal melanomas are made of two distinctive cell types, spindle and epitheloid, with differing clinical implications. These melanomas are known to be less aggre-ssive malignant tumours comparing to the cutaneous type of same cell characteristic (1). The intent of this short study was to investigate expression of Ki-67 immunocomplex in uveal melanoma cells, examine if intensity of expression correlates with levels of invasion, which would result in prognostic significance. 19 uveal melanomas were tested for the presence of Ki-67 protein by indirect peroxidase antiperoxidase method and monodonal antibody for Ki-67 protein. The intensity of the reaction is marked by a semi-quantative method. All samples of epitheloid melanomas showed strongly positive Ki-67 reaction. Spindle B cells, which are a transi-tional type between epitheloid and spindle A cells, show greater variation in Ki-67 expression, from negative to moderately positive.

KI 67 antigen; melanomas

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