engleski

Neutral effect of Glioma-associated oncogene-1 expression on survival in myelofibrosis

This study retrospectively analyzed gliomaassociated oncogene 1 (GLI-1) mRNA expression in unfractionated bone marrow aspirates of 32 patients with myelofibrosis and 16 controls. It was found that GLI-1 expression did not significantly differ between primary, secondary myelofibrosis and controls (median difference in threshold cycles ΔCT 7.2, 7.3 and 6.9, respectively ; P= 0.864), as well as that survival curves of myelofibrosis patients with higher/lower GLI-1 expression showed multiple overlaps and overall comparable course (P= 0.651). The results suggest that general upregulation of GLI-1 does not seem to be a feature of the disease and are in line with modest biological and clinical effects observed with inhibitors of Hedgehog signaling pathway in patients with myelofibrosis.

Philadelphia negative myeloproliferative neoplasm · Bone marrow fibrosis · Sonic Hedgehog · Smoothened

nije evidentirano