engleski

Dendriform pulmonary ossifications – our experience and literature review

Idiopathic pulmonary ossifications (IPO) are rare pulmonary disorders. IPO occur as a pathomorphologic pulmonary finding in different pulmonary and systemic diseases. IPO forms are metaplastic processess of the ectopic osteogenesis characterized by the presence of the bone tissue in the pulmonary interstitium or alveolar walls. Suggested etiopathogenetic factors such as lung congestion in mitral stenosis with cardiac decompensation, pulmonary fibrosis, and local milieu acidification due to gastroesophageal reflux disease and other recidive aspirations of gastric acid content can none be objectivelly confirmed for the time being and details of DPOs etiopathogenesys remain unknown. The literature does not provide exact epidemiologic data because published papers mainly consists of individual case reports. We performed a retrospective study at our Department of Diagnostic and Interventional Radiology. Thorax multislice computed tomography, chest x-ray, and pathohistological analysis of the lung needle biopsy specimens were analysed as well as the patients medical data. We show some pulmonary and non - pulmonary comorbidities and associated pathological findings on thorax MSCTs in patients with confirmed PO. Also we show a radiological and pathohistological characteristics of the PO specimens obtained by lung needle biopsy. According to our results IPO are associated with inflammatory, obstructive and restrictive profile of the pulmonary disorders and it is not strictly combined with usual interstitial pneumonia pattern. In the clinical approach to PO patients, neurological and gastroenterological disorders should be considered, because such conditions include repeated aspirations of the acid content.

Idiopathic pulmonary ossifications ; radiology imaging

Rad je izrađen u Kliničkom zavodu za dijagnostičku i intervencijsku radiologiju Kliničke bolnice Dubrava u Zagrebu.