Better quality of life and adherence with less adverse events when switching from oral to subcutaneous methotrexate: results of the six- month observational prospective study in Croatia (CROSBI ID 718102)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa
Podaci o odgovornosti
Grazio, Simeon ; Perković, Dijana ; Laktašić Žerjavić, Nadica ; Grubišić, Frane ; Glasnović, Marija ; Gudelj Gračanin, Ana ; Kolak, Željka ; Kolar Mitrović, Helena ; Morović Vergles, Jadranka ; Perić, Porin ; Šimac, Petra ; Žagar, Iva ; Doko, Ines ; Trkulja, Vladimir
engleski
Better quality of life and adherence with less adverse events when switching from oral to subcutaneous methotrexate: results of the six- month observational prospective study in Croatia
Background: It has been demonstrated that bioavailability of oral (P.O.) MTX reaches plateau at doses ≥15 mg QW, and that subcutaneous (S.C.) form has a better efficacy. Alongside with less side-effects this might translate into improvement in quality of life (QoL) and better adherence. Objectives: An academic-induced observational longitudinal study of patients with RA and peripheral form of PsA on csDMARDs who were switched from oral (P.O.) to subcutaneous (S.C.) MTX was conducted. Previously we reported on the better efficacy of S.C. compared to P.O. MTX. The objective of this part of the study we are presenting was to evaluate the 6-month changes in quality of life (QoL), adverse events and adherence in these patients. Methods: Forty-eight consecutive patients (79.2% women) with established diagnosis of RA (77.1%) and peripheral PsA were enrolled from the outpatient clinics in six centres in Croatia. Median age was 61 (39-79) years, and the median of disease duration was 120 (3-528) months. Data were collected at baseline (T0) (on P.O. MTX), at day 90 (±10 days) (T1) and at day 180 (±10 days) (T2), during S.C. MTX treatment. Median dose of MTX remained stable during the study (15mg QW). At each visit QoL was measured using EuroQuol-5D (EQ- 5D), adverse events related to MTX use were recorded, and adherence by the number of missed dose. Results: EQ-5D global health assessment showed significant improvement in quality of life of patients on S.C. MTX during the 6 month follow-up (change from T0 to T2 8.6 ; 95%CI 4.00, 13.3), and the same trend was observed in each of its five component. Number of patients who experienced adverse events related to MTX use has decrease after switching from P.O. to S.C.MTX – from 52.1% during the last 3 months on P.O. MTX to 33.3% during the first 3 months and 18.2% during the last 3 months of S.C. MTX use. During the follow- up adherence to MTX therapy improved, with 25% of patients who missed dose during the last 3 months on P.O. MTX use, to 6, 3% and 2.3% with missed dose in the first and the last 3 months on S.C. MTX, respectively. Conclusion: In our group of patients with RA and peripheral PsA who switched from P.O. to S.C. MTX there was a consistent improvement in QoL, less adverse-events and better adherence.
rheumatoid arthritis ; methotrexate ; switching ; quality of life
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Podaci o prilogu
1471-1471.
2020.
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objavljeno
10.1136/annrheumdis-2020-eular.4849
Podaci o matičnoj publikaciji
Annals of rheumatic diseases
London : Delhi: BMJ
0003-4967
1468-2060
Podaci o skupu
Annual European Congress of Rheumatology (EULAR 2020)
poster
03.06.2020-06.06.2020
online
Povezanost rada
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Kliničke medicinske znanosti