engleski

The role of GABA neurotransmitter in the regulation of endocervical mucus secretion

The cervix is an important factor in a woman s fertility and reproductive health. The folds in the mucosa of the cervical canal, the so-called endocervical crypts or endocervical glands , produce cervical mucos. By its biochemical composition, cervical mucus is a glycoprotein gel. Its production and its biochemical and biophysical characteristics are hormonally regulated. cervical mucus, in addition to its protective function, plays an important role in fertility as it accepts, nourishes and protects sperm and helps transfer it to the ovum for fertilization. The mechanism of cellular regulation of mucus production of different properties, and their release into the lumen of the cervix, in only partially known. The aim of this study was to elucidate part of the mechanism of cervical mucus secretion, guided by the proposed model of the involvement of the neurotransmitter GABA in the hormonal regulation of mucus secretion. The study was performed on fixed samplee of cervical tissue obtained after hysterectomy (surgical removal oh the uterus). The most important results of this study show the presence GABA-ergic signaling pathway molecules in the glandular epithelium of cervical tissue. The results established that the presence of receptor A for the neurotrasnsmitter GABA did not correlate with the phase of the patient s cycle at the time of sampling. Analysis of the results of the study also showed that the presence of receptor A for th neurotransmitter GABA is more common in the upper endocervix than in the lower one. These results certainly contribute to the debate about thje role of the GABA signaling pathway in mucus secretion. Fixed cervical tissue samples obtained after hysterectomy are an affordable and good model for preliminary examination of hypothetical proposals for the mechanism of regulation of endocervical mucus formation and secretion, but not for reaching a definitive conclusion on the proposed hypotheses

infertility ; mucus ; cervix

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