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Pregled bibliografske jedinice broj: 1194779

Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction


Vukičević, Slobodan; Colliva, Andrea; Kufner, Vera; Martinelli, Valentina; Moimas, Silvia; Vodret, Simone; Rumenović, Viktorija; Milošević, Milan; Brkljačić, Boris; Delić-Brkljačić, Diana et al.
Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction // Nature communications, 13 (2022), 81, 11 doi:10.1038/s41467-021-27622-9 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1194779 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction

Autori
Vukičević, Slobodan ; Colliva, Andrea ; Kufner, Vera ; Martinelli, Valentina ; Moimas, Silvia ; Vodret, Simone ; Rumenović, Viktorija ; Milošević, Milan ; Brkljačić, Boris ; Delić-Brkljačić, Diana ; Correa, Ricardo ; Giacca, Mauro ; Maglione, Manuel ; Bordukalo Nikšić, Tatjana ; Dumić-Čule, Ivo ; Zacchigna, Serena

Izvornik
Nature communications (2041-1723) 13 (2022); 81, 11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
BMP1.3 ; antibody ; ishemic heart disease ; collagen

Sažetak
Despite the high prevalence of ischemic heart diseases worldwide, no antibody-based treatment currently exists. Starting from the evidence that a specific isoform of the Bone Morphogenetic Protein 1 (BMP1.3) is particularly elevated in both patients and animal models of myocardial infarction, here we assess whether its inhibition by a specific monoclonal antibody reduces cardiac fibrosis. We find that this treatment reduces collagen deposition and cross-linking, paralleled by enhanced cardiomyocyte survival, both in vivo and in primary cultures of cardiac cells. Mechanistically, we show that the anti-BMP1.3 monoclonal antibody inhibits Transforming Growth Factor β pathway, thus reducing myofibroblast activation and inducing cardioprotection through BMP5. Collectively, these data support the therapeutic use of anti-BMP1.3 antibodies to prevent cardiomyocyte apoptosis, reduce collagen deposition and preserve cardiac function after ischemia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
EK-EFRR-KK.01.1.1.01.0008 - Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu – istraživanja novih platormi i potencijala (CERRM) (Volarević, Siniša; Vukičević, Slobodan; Ježek, Davor, EK - KK.01.1.1.01) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Klinička bolnica "Dubrava"

Poveznice na cjeloviti tekst rada:

doi www.nature.com www.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Vukičević, Slobodan; Colliva, Andrea; Kufner, Vera; Martinelli, Valentina; Moimas, Silvia; Vodret, Simone; Rumenović, Viktorija; Milošević, Milan; Brkljačić, Boris; Delić-Brkljačić, Diana et al.
Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction // Nature communications, 13 (2022), 81, 11 doi:10.1038/s41467-021-27622-9 (međunarodna recenzija, članak, znanstveni)
Vukičević, S., Colliva, A., Kufner, V., Martinelli, V., Moimas, S., Vodret, S., Rumenović, V., Milošević, M., Brkljačić, B. & Delić-Brkljačić, D. (2022) Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction. Nature communications, 13, 81, 11 doi:10.1038/s41467-021-27622-9.
@article{article, author = {Vuki\v{c}evi\'{c}, Slobodan and Colliva, Andrea and Kufner, Vera and Martinelli, Valentina and Moimas, Silvia and Vodret, Simone and Rumenovi\'{c}, Viktorija and Milo\v{s}evi\'{c}, Milan and Brklja\v{c}i\'{c}, Boris and Deli\'{c}-Brklja\v{c}i\'{c}, Diana and Correa, Ricardo and Giacca, Mauro and Maglione, Manuel and Bordukalo Nik\v{s}i\'{c}, Tatjana and Dumi\'{c}-\v{C}ule, Ivo and Zacchigna, Serena}, year = {2022}, pages = {11}, DOI = {10.1038/s41467-021-27622-9}, chapter = {81}, keywords = {BMP1.3, antibody, ishemic heart disease, collagen}, journal = {Nature communications}, doi = {10.1038/s41467-021-27622-9}, volume = {13}, issn = {2041-1723}, title = {Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction}, keyword = {BMP1.3, antibody, ishemic heart disease, collagen}, chapternumber = {81} }
@article{article, author = {Vuki\v{c}evi\'{c}, Slobodan and Colliva, Andrea and Kufner, Vera and Martinelli, Valentina and Moimas, Silvia and Vodret, Simone and Rumenovi\'{c}, Viktorija and Milo\v{s}evi\'{c}, Milan and Brklja\v{c}i\'{c}, Boris and Deli\'{c}-Brklja\v{c}i\'{c}, Diana and Correa, Ricardo and Giacca, Mauro and Maglione, Manuel and Bordukalo Nik\v{s}i\'{c}, Tatjana and Dumi\'{c}-\v{C}ule, Ivo and Zacchigna, Serena}, year = {2022}, pages = {11}, DOI = {10.1038/s41467-021-27622-9}, chapter = {81}, keywords = {BMP1.3, antibody, ishemic heart disease, collagen}, journal = {Nature communications}, doi = {10.1038/s41467-021-27622-9}, volume = {13}, issn = {2041-1723}, title = {Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction}, keyword = {BMP1.3, antibody, ishemic heart disease, collagen}, chapternumber = {81} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index


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