engleski

Inclusion complexes of ferrocene uracil derivatives with cyclodextrins: solubilization and binding ability

Recent research shows that ferrocene uracil derivatives have biological activity. However, their high lipophilicity limits the application. It is known that cyclodextrins show abillity to improve drug water solubility by binding the hidrophobic moiety of the molecule inside of its cavity, such as ferrocene.2 Ferrocene shows different binding orientations as well as binding constants for alpha, beta and gama cyclodextrine in water.3 Environment of ferrocene can influence their binding to cyclodextrines. Therefore, we researched various ferocene uracyl derivatives with different R’, R groups and studied their binding ability with α-cyclodextrin, β- cyclodextrin, γ-cyclodextrin and modified (2- hydroxypropyl)-β-cyclodextrin in water. Characterisation was preformed using UV-Vis spectroscopy. Titrations were used to calculate binding constants that show range between.

complex ; ferrocene uracil ; cyclodextrin

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