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Design and synthesis of new supramolecular nano- structured materials based on peptide hydrogelator Ac-L-Phe-L-Phe-L-Ala-NH2 and embedded liposomes

The aim of the present study was preparation and characterization of supramolecular systems based on peptide hydrogelator Ac-L-Phe-L-Phe-L-Ala-NH2 and liposomes. In recent years design and synthesis of self-assembled nanomaterials with diversified structures and functionalities via fine tuning of supramolecular building blocks increased rapidly. Liposomes have been researched for their ability to reduce side effects and improve drug delivery. Lipid carrier and hydrogel combinations offer oral and transdermal drug delivery of great potential to enhance systemic effects of both hydrophilic and lipophilic drugs. Self-assembling peptides have been widely recognized as nanomaterials with high potential for an extensive range of biomedical applications from drug delivery to tissue engineering, owing to their hydrophilic character and biocompatibility. The gelling properties of the hydrogelator Ac-L-Phe-L-Phe-L-Ala-NH2 with addition of liposomes and proteins were studied. Liposome formulations of bovine serum albumin (BSA) incorporated in the hydrogel were characterized by electron microscopy. Transmission electron microscopy (TEM) confirmed incorporation of liposomes into the hydrogel. In gel samples with built-in BSA, the gel network preserved integrity, but it was noticed that the gel fibers were thinner and longer. It was also shown that liposomes do not impair the gel network of hydrogelator at lipid concentrations lower than the gelator concentration. We confirmed that use of higher amounts of protein albumin BSA resulted in slower gel formation or inability to transition into gel.

nano-structured materials ; peptide hydrogelator ; liposomes

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